Efficacy of Morphine in Reducing the Rate of Early Non-Invasive Ventilation Failure in Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Phase I/IIa (MORPHEUS I/IIa)

2024-516085-11-00 Phase I and Phase II (Integrated) - Other Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - Other
Status Authorised, recruitment pending
Participants planned 24
Countries 1
Sites 1

Chronic Obstructive Pulmonary Disease

Key facts

Sponsor
Centre Hospitalier Universitaire Grenoble Alpes
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Respiratory Tract Diseases [C08]
Decision date (initial)
2024-10-07
Transition trial
Yes
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2024-516085-11-00
EudraCT number
2019-004274-25
ClinicalTrials.gov
NCT04427826

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Chronic Obstructive Pulmonary Disease

VersionLevelCodeTermSystem organ class
26.1 PT 10009033 Chronic obstructive pulmonary disease 100000004855
26.1 PT 10009033 Chronic obstructive pulmonary disease 100000004855

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Centre Hospitalier Universitaire Grenoble Alpes

Sponsor organisation
Centre Hospitalier Universitaire Grenoble Alpes
Address
Boulevard De La Chantourne, Cs 10217, La Tronche Cs 10217 La Tronche
City
Grenoble Cedex 9
Postcode
38043
Country
France

Scientific contact point

Organisation
Centre Hospitalier Universitaire Grenoble Alpes
Contact name
Damien VIGLINO

Public contact point

Organisation
Centre Hospitalier Universitaire Grenoble Alpes
Contact name
Damien VIGLINO

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Authorised, recruitment pending 24 1
Rest of world 0

Investigational sites

France

1 site · Authorised, recruitment pending
Centre Hospitalier Universitaire Grenoble Alpes
Service des urgences adulte, Boulevard De La Chantourne, Cs 10217, Grenoble Cedex 9

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-08-09 France Acceptable
2024-10-07
2024-10-07
2 SUBSTANTIAL MODIFICATION SM-1 2025-10-30 France Acceptable
2025-12-11
2025-12-11