A bioavailability study of epinephrine following a single dose of emergency response auto-injector in comparison to epinephrine injection into muscle via syringe in healthy adults.

2024-516575-32-00 Protocol EPIN-IJS-1002 Human pharmacology (Phase I) - Other Ended

Start 10 Jan 2025 · End 17 May 2025 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol EPIN-IJS-1002

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 12
Countries 1
Sites 1

Allergic reactions (Type 1), including anaphylaxis, idiopathic anaphylaxis or exercise-induced anaphylaxis

Key facts

Sponsor
Mylan Pharmaceuticals Inc.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
10 Jan 2025 → 17 May 2025
Decision date (initial)
2024-12-05
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Allergic reactions (Type 1), including anaphylaxis, idiopathic anaphylaxis or exercise-induced anaphylaxis

VersionLevelCodeTermSystem organ class
20.1 LLT 10001718 Allergic reaction 10021428

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Mylan Pharmaceuticals Inc.

Sponsor organisation
Mylan Pharmaceuticals Inc.
Address
3711 Collins Ferry Road
City
Morgantown
Postcode
26505-2362
Country
United States

Scientific contact point

Organisation
Mylan Pharmaceuticals Inc.
Contact name
EUClinicalTrials@viatris

Public contact point

Organisation
Mylan Pharmaceuticals Inc.
Contact name
EUClinicalTrials@viatris

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 12 1
Rest of world 0

Investigational sites

Germany

1 site · Ended
PAREXEL International GmbH
#001: Parexel Early Phase Unit Berlin, Klinikum Westend Haus 31, Spandauer Damm 130, Berlin

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2025-01-10 2025-05-16 2025-01-10 2025-05-14

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-10-04 Germany Acceptable
2024-12-04
2024-12-05