A trial to learn how ceralasertib affects the way certain medications move throughout the body over time and how safe it is to use ceralasertib with these medications in adults with advanced solid tumors

2024-516611-24-00 Protocol D533BC00003 Human pharmacology (Phase I) - Other Not authorised

Status Not authorised · 1 EU/EEA countries · 3 sites · Protocol D533BC00003

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Not authorised
Participants planned 20
Countries 1
Sites 3

Advanced solid tumour

Key facts

Sponsor
AstraZeneca AB
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Decision date (initial)
2025-05-13
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Advanced solid tumour

VersionLevelCodeTermSystem organ class
21.1 LLT 10065143 Malignant solid tumour 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

AstraZeneca AB

Sponsor organisation
AstraZeneca AB
Address
-
City
Sodertalje
Postcode
151 85
Country
Sweden

Scientific contact point

Organisation
AstraZeneca AB
Contact name
AstraZeneca Clinical Study Information Center

Public contact point

Organisation
AstraZeneca AB
Contact name
AstraZeneca Clinical Study Information Center

Locations

1 EU/EEA country · 3 investigational sites

By country

CountryMS statusPlanned subjectsSites
Spain Not authorised 18 3
Rest of world
United Kingdom
2

Investigational sites

Spain

3 sites · Not authorised
Hospital Universitario Fundacion Jimenez Diaz
#7002:Medical Oncology, Avenida De Los Reyes Catolicos 2, 28040, Madrid
Hospital Hm Nou Delfos
#7003;Medical Oncology, Avinguda De Vallcarca 151, 08023, Barcelona
Hospital Universitario Hm Sanchinarro
#7001:Medical Oncology, Calle Ona 10, 28050, Madrid

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-01-28 Spain Not acceptable
2025-05-09
2025-05-13