Differences in absorption via oral route and via oral mucosa of hydrocortisone from 2-dimensionally printed dissolvable films in healthy volunteers and in adult patients with adrenal insufficiency.

2024-517298-26-00 Protocol K804 Human pharmacology (Phase I) - Bioequivalence study Ongoing, recruiting

Start 21 May 2025 · Status Ongoing, recruiting · 1 EU/EEA countries · 2 sites · Protocol K804

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ongoing, recruiting
Participants planned 26
Countries 1
Sites 2

adrenal insufficiency

Key facts

Sponsor
Universitaetsklinikum Heidelberg AöR
Participant type
Patients, Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Nutritional and Metabolic Diseases [C18]
Trial duration
21 May 2025 → ongoing
Decision date (initial)
2025-03-12
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

adrenal insufficiency

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Universitaetsklinikum Heidelberg AöR

Sponsor organisation
Universitaetsklinikum Heidelberg AöR
Address
Im Neuenheimer Feld 672, Neuenheim Neuenheim
City
Heidelberg
Postcode
69120
Country
Germany

Scientific contact point

Organisation
Universitaetsklinikum Heidelberg AöR
Contact name
Prof. Dr. med. Antje Blank

Public contact point

Organisation
Universitaetsklinikum Heidelberg AöR
Contact name
Prof. Dr. med. Antje Blank

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ongoing, recruiting 26 2
Rest of world 0

Investigational sites

Germany

2 sites · Ongoing, recruiting
Universitaetsklinikum Heidelberg AöR
Endocrinology, Im Neuenheimer Feld 410, Neuenheim, Heidelberg
Universitaetsklinikum Heidelberg AöR
KliPS, Im Neuenheimer Feld 410, Neuenheim, Heidelberg

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2025-05-21 2025-06-24

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-01-09 Germany Acceptable
2025-03-12
2025-03-12
2 SUBSTANTIAL MODIFICATION SM-1 2025-03-31 Germany Acceptable
2025-04-09
2025-04-15