Evaluation of the bioavailability of two transdermal gel preparations containing 0.1% w/w estradiol under fasting conditions: Estradiol/INTERMED gel 0.1% w/w (Test) vs. ESTREVA® 0.1%, gel (Comparator). A monocentric, open, randomized, single dose, two-period, crossover trial in healthy postmenopausal women

2024-517969-16-00 Protocol CIM24001 Human pharmacology (Phase I) - Other Ended

Start 12 Mar 2025 · End 15 Apr 2025 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol CIM24001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 18
Countries 1
Sites 1

No therapeutic indication in the current trial with healthy volunteers.

Key facts

Sponsor
CCDRD Cooperative Clinical Drug Research and Development AG, Ioulia And Irene Tseti Pharmaceutical Laboratories S.A.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Female
Therapeutic area
Phenomena and Processes [G] - Physiological processes [G07]
Trial duration
12 Mar 2025 → 15 Apr 2025
Decision date (initial)
2025-02-21
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

No therapeutic indication in the current trial with healthy volunteers.

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

CCDRD Cooperative Clinical Drug Research and Development AG

Sponsor organisation
CCDRD Cooperative Clinical Drug Research and Development AG
Address
Dahlwitz, Lindenallee 70, Dahlwitz-Hoppegarten Lindenallee 70 Dahlwitz-Hoppegarten
City
Hoppegarten
Postcode
15366
Country
Germany

Scientific contact point

Organisation
CCDRD Cooperative Clinical Drug Research and Development AG
Contact name
Project Manager

Public contact point

Organisation
CCDRD Cooperative Clinical Drug Research and Development AG
Contact name
Project Manager

Ioulia And Irene Tseti Pharmaceutical Laboratories S.A.

Sponsor organisation
Ioulia And Irene Tseti Pharmaceutical Laboratories S.A.
Address
Kaliftaki 27
City
Kifisia
Postcode
145 64
Country
Greece

Scientific contact point

Organisation
Ioulia And Irene Tseti Pharmaceutical Laboratories S.A.
Contact name
Head of RA

Public contact point

Organisation
Ioulia And Irene Tseti Pharmaceutical Laboratories S.A.
Contact name
Head of RA

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Bulgaria Ended 18 1
Rest of world 0

Investigational sites

Bulgaria

1 site · Ended
Bed space for short term stay at Diagnostic & Consultative Centre 'Ascendent' Ltd.
Diagnostic & Consultative Centre 'Ascendent' Ltd., 47 'Bacho Kiro' str., 1202, Sofia

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Bulgaria 2025-03-12 2025-04-15 2025-03-12 2025-03-21

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-11-12 Bulgaria Acceptable
2025-02-20
2025-02-21