A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellitus

2024-518470-13-00 Protocol J1I-MC-GZQG Human pharmacology (Phase I) - Other Ongoing, recruiting

Start 30 May 2025 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol J1I-MC-GZQG

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ongoing, recruiting
Participants planned 95
Countries 1
Sites 1

Diabetes Mellitus

Key facts

Sponsor
Eli Lilly & Co.
Participant type
Patients
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Phenomena and Processes [G] - Metabolism [G03]
Trial duration
30 May 2025 → ongoing
Decision date (initial)
2025-04-11
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2024-518470-13-00
WHO UTN
U1111-1316-7607

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Diabetes Mellitus

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Eli Lilly & Co.

Sponsor organisation
Eli Lilly & Co.
Address
1 Lilly Corporate Center
City
Indianapolis
Postcode
46285-0001
Country
United States

Scientific contact point

Organisation
Eli Lilly & Co.
Contact name
Lilly Clinical Trials information desk

Public contact point

Organisation
Eli Lilly & Co.
Contact name
Lilly Clinical Trials information desk

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ongoing, recruiting 95 1
Rest of world 0

Investigational sites

Germany

1 site · Ongoing, recruiting
PROFIL Institut fuer Stoffwechselforschung GmbH
NA, Hellersbergstrasse 9, Hammfeld, Neuss

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2025-05-30 2025-06-02

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-02-14 Germany Acceptable
2025-04-08
2025-04-11
2 SUBSTANTIAL MODIFICATION SM-1 2026-01-16 Germany Acceptable
2026-01-30
2026-02-03