A Study of LY4057996 in Healthy Participants and Participants with Type 1 and Type 2 Diabetes (YKAA)

2024-519151-28-00 Protocol J6B-MC-YKAA Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 14 May 2025 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol J6B-MC-YKAA

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 132
Countries 1
Sites 1

Healthy, Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2

Key facts

Sponsor
Eli Lilly & Co.
Participant type
Patients, Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Nutritional and Metabolic Diseases [C18]
Trial duration
14 May 2025 → ongoing
Decision date (initial)
2025-04-24
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2024-519151-28-00
WHO UTN
U1111-1315-8487

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy, Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Eli Lilly & Co.

Sponsor organisation
Eli Lilly & Co.
Address
1 Lilly Corporate Center
City
Indianapolis
Postcode
46285-0001
Country
United States

Scientific contact point

Organisation
Eli Lilly & Co.
Contact name
Lilly Clinical Trials information desk

Public contact point

Organisation
Eli Lilly & Co.
Contact name
Lilly Clinical Trials information desk

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ongoing, recruiting 132 1
Rest of world 0

Investigational sites

Germany

1 site · Ongoing, recruiting
PROFIL Institut fuer Stoffwechselforschung GmbH
NA, Hellersbergstrasse 9, Hammfeld, Neuss

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2025-05-14 2025-05-16

Application history

4 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-02-10 Germany Acceptable
2025-04-23
2025-04-24
2 SUBSTANTIAL MODIFICATION SM-1 2025-06-05 Germany Acceptable 2025-07-03
3 SUBSTANTIAL MODIFICATION SM-2 2025-07-16 Germany Acceptable
2025-08-07
2025-08-12
4 SUBSTANTIAL MODIFICATION SM-3 2026-03-02 Germany Acceptable
2026-03-18
2026-03-20