A first-in-human trial to evaluate safety, tolerability, and pharmacokinetics of single and multiple oral doses of Debio 1453P in healthy adults

2024-519328-26-01 Protocol Debio 1453-101 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 18 Jun 2025 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol Debio 1453-101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 112
Countries 1
Sites 1

Sexual Transmitted Infection (STI)

Key facts

Sponsor
Debiopharm International S.A.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Bacterial Infections and Mycoses [C01]
Trial duration
18 Jun 2025 → ongoing
Decision date (initial)
2025-06-03
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2024-519328-26-01
WHO UTN
U1111-1315-2035

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Sexual Transmitted Infection (STI)

VersionLevelCodeTermSystem organ class
20.0 PT 10018612 Gonorrhoea 100000004862

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Debiopharm International S.A.

Sponsor organisation
Debiopharm International S.A.
Address
Forum Apres-Demain, Chemin Messidor 5-7 Chemin Messidor 5-7
City
Lausanne
Postcode
1006
Country
Switzerland

Scientific contact point

Organisation
Debiopharm International S.A.
Contact name
-

Public contact point

Organisation
Debiopharm International S.A.
Contact name
-

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Belgium Ongoing, recruiting 112 1
Rest of world 0

Investigational sites

Belgium

1 site · Ongoing, recruiting
SGS Belgium
SGS Belgium NV – Clinical Pharmacology Unit, Drie Eikenstraat 655, 2650, Edegem

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Belgium 2025-06-18 2025-06-18

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-04-10 Belgium Acceptable with conditions
2025-05-23
2025-06-03
2 SUBSTANTIAL MODIFICATION SM-1 2026-03-10 Belgium Acceptable with conditions
2026-04-27
2026-04-27