A phase 1, double-blind, placebo-controlled, randomized, single ascending dose and multiple ascending dose study to assess the safety, tolerability, and pharmacokinetics of GHF-201 in healthy adult volunteers

2024-519813-74-00 Protocol CGH24001 Human pharmacology (Phase I) - Other Ended

Start 27 Jun 2025 · End 19 Jan 2026 · Status Ended · 1 EU/EEA countries · 2 sites · Protocol CGH24001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 32
Countries 1
Sites 2

Adult polyglucosan body disease (APBD).

Key facts

Sponsor
CCDRD Cooperative Clinical Drug Research and Development AG, GHF-Golden Heart Flower Ltd.
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Trial duration
27 Jun 2025 → 19 Jan 2026
Decision date (initial)
2025-04-17
Transition trial
No
Low-intervention
No
Rare-disease indication
Yes
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Adult polyglucosan body disease (APBD).

VersionLevelCodeTermSystem organ class
20.0 PT 10077946 Adult polyglucosan body disease 100000004850

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

CCDRD Cooperative Clinical Drug Research and Development AG

Sponsor organisation
CCDRD Cooperative Clinical Drug Research and Development AG
Address
Dahlwitz, Lindenallee 70, Dahlwitz-Hoppegarten Lindenallee 70 Dahlwitz-Hoppegarten
City
Hoppegarten
Postcode
15366
Country
Germany

Scientific contact point

Organisation
GHF-Golden Heart Flower Ltd.
Contact name
Head of Product Development: Yossi Gilgun-Sherki

Public contact point

Organisation
GHF-Golden Heart Flower Ltd.
Contact name
Head of Product Development: Yossi Gilgun-Sherki

GHF-Golden Heart Flower Ltd.

Sponsor organisation
GHF-Golden Heart Flower Ltd.
Address
4, Ha-Amal
City
Afula
Postcode
1857109
Country
Israel

Scientific contact point

Organisation
GHF-Golden Heart Flower Ltd.
Contact name
Head of Product Development: Yossi Gilgun-Sherki, PhD, MBA

Public contact point

Organisation
GHF-Golden Heart Flower Ltd.
Contact name
Head of Product Development: Yossi Gilgun-Sherki, PhD, MBA

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Bulgaria Ended 32 2
Rest of world 0

Investigational sites

Bulgaria

2 sites · Ended
Multidisciplinary Hospital for Active Treatment (MHAT) Evropa OOD
Department of gastroenterology, 2, Pencho Slaveikov Str., Sofia
Clinic of Clinical Pharmacology and Therapeutics UMHAT 'Tsaritsa Ioanna-ISUL' EAD
Clinic of Clinical Pharmacology and Therapeutics, 8 'Bialo more' Str., 1527, Sofia

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Bulgaria 2025-06-27 2026-01-19 2025-06-27 2025-12-30

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-12-20 Bulgaria Acceptable
2025-04-15
2025-04-17