A trial to learn if itraconazole and carbamazepine affect how AZD5462 moves throughout the bodies of healthy adults

2024-519834-21-00 Protocol AZD5462-D9090C00012 Human pharmacology (Phase I) - Other Ended

End 14 Jul 2025 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol AZD5462-D9090C00012

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 42
Countries 1
Sites 1

Chronic Heart Failure

Key facts

Sponsor
AstraZeneca AB
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Cardiovascular Diseases [C14]
Trial duration
completed 14 Jul 2025
Decision date (initial)
2025-04-22
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Chronic Heart Failure

VersionLevelCodeTermSystem organ class
20.0 LLT 10008908 Chronic heart failure 10007541

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

AstraZeneca AB

Sponsor organisation
AstraZeneca AB
Address
-
City
Sodertalje
Postcode
151 85
Country
Sweden

Scientific contact point

Organisation
AstraZeneca AB
Contact name
AstraZeneca Clinical Study Information Centre

Public contact point

Organisation
AstraZeneca AB
Contact name
AstraZeneca Clinical Study Information Centre

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 42 1
Rest of world 0

Investigational sites

Germany

1 site · Ended
PAREXEL International GmbH
2601: Parexel Early Phase Unit Berlin, Klinikum Westend Haus 31, Spandauer Damm 130, Berlin

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-02-14 Germany Acceptable
2025-04-04
2025-04-22