Lantiolihaspuudutuksen vaikutus munuaisen poistoleikkauksen jälkeiseen kivun hoitoon ja toipumiseen

2024-519910-30-00 Protocol QLB-N-2017 Therapeutic use (Phase IV) Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites · Protocol QLB-N-2017

Overview

Sponsor-declared trial summary

Phase Therapeutic use (Phase IV)
Status Authorised, recruitment pending
Participants planned 90
Countries 1
Sites 1

Renal cancer

Does Quadratus lumborum block diminish the need for rescue analgesia

Key facts

Sponsor
Pirkanmaan hyvinvointialue
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Decision date (initial)
2025-01-21
Transition trial
Yes
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2024-519910-30-00
EudraCT number
2017-002254-37

Trial design

CTIS Part I — objectives, methods, condition coding

Main objective

Scope: Safety, Therapy, Efficacy

Does Quadratus lumborum block diminish the need for rescue analgesia

Conditions and MedDRA coding

Renal cancer

Eligibility criteria

Principal inclusion / exclusion criteria as submitted by sponsor

Inclusion criteria 1

  1. Munuaissyöpäpotilaat, joille suoritetaan laparoskooppinen radikaali nefrektomia

Exclusion criteria 10

  1. Alle 18 vuoden ikä
  2. Komplisoitunut tyypin 1 diabetes
  3. Puutteellinen suomen kielen taito
  4. Ko-operaation puute
  5. Pitkittynyt kiputila muun syyn takia
  6. Ei sovellu laparoskooppiseen leikkaukseen
  7. Hankala maksan vajaatoiminta tai Parasetamoli ei sovi musta syystä
  8. Kortisonilääkitys kotilääkityksissä
  9. Ei pysty käyttämään oksikodonia
  10. Oksikodonin ja parasetamolin metaboliaan vaikuttavien lääkkeiden säännöllinen käyttö (mysiini-antibiootit, makrolidit, masennuslääkkeet, antiepileptit ja probenisidi)

Endpoints

Primary and secondary outcome measures (English text)

Primary endpoints 1

  1. kumulatiivinen opiaatin kulutus 1, 2, 4, 8, 12, 16 ja 24 tuntia puudutuksen jälkeen

Secondary endpoints 2

  1. Aika puudutuksen laitosta ensimmäisen kipulääkkeen tarpeeseen
  2. kipu levossa/liikkeellä

Investigational products

Investigational medicinal products (IMPs), comparators, placebo, auxiliary

Test 2

Ropivacain Fresenius Kabi 7,5 mg/ml injektioneste, liuos

PRD767207 · Product

Active substance
Ropivacaine Hydrochloride
Pharmaceutical form
SOLUTION FOR INJECTION
Route of administration
INJECTION
Max daily dose
675 mg milligram(s)
Max total dose
675 mg milligram(s)
Max treatment duration
1 Day(s)
Authorisation status
Authorised
ATC code
N01BB09 — ROPIVACAINE
Marketing authorisation
27494
MA holder
FRESENIUS KABI AB
MA country
Finland
Paediatric formulation
No
Orphan designation
No
Modified vs. Marketing Authorisation
No

Dexamethasone Kabi 4 mg/ml solution for injection/infusion

PRD9554327 · Product

Active substance
Dexamethasone Sodium Phosphate
Pharmaceutical form
SOLUTION FOR INJECTION
Route of administration
INJECTION
Max daily dose
100 mg milligram(s)
Max total dose
100 mg milligram(s)
Max treatment duration
1 Day(s)
Authorisation status
Authorised
ATC code
H02AB02 — DEXAMETHASONE
Marketing authorisation
20220062
MA holder
FRESENIUS KABI BULGARIA EOOD
MA country
Bulgaria
Paediatric formulation
No
Orphan designation
No
Modified vs. Marketing Authorisation
No

Placebo 1

Natriumchloride Fresenius Kabi 100 mg/ml (10%), concentraat voor oplossing voor infusie

PRD2541503 · Product

Active substance
Sodium Chloride
Pharmaceutical form
SOLUTION FOR INFUSION
Route of administration
INJECTION
Max daily dose
30 ml millilitre(s)
Max total dose
30 ml millilitre(s)
Max treatment duration
1 Day(s)
Authorisation status
Authorised
ATC code
B05XA03 — SODIUM CHLORIDE
Marketing authorisation
RVG 103379
MA holder
FRESENIUS KABI NEDERLAND B.V.
MA country
Netherlands
Paediatric formulation
No
Orphan designation
No
Modified vs. Marketing Authorisation
No

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Pirkanmaan hyvinvointialue

Sponsor organisation
Pirkanmaan hyvinvointialue
Address
Elamanaukio 2
City
Tampere
Postcode
33520
Country
Finland

Scientific contact point

Organisation
Pirkanmaan hyvinvointialue
Contact name
Maija-Liisa Kalliomäki

Public contact point

Organisation
Pirkanmaan hyvinvointialue
Contact name
Maija-Liisa Kalliomäki

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Finland Authorised, recruitment pending 90 1
Rest of world 0

Investigational sites

Finland

1 site · Authorised, recruitment pending
Tampere University Hospital
Intensive care unit, Elamanaukio 2, 33520, Tampere

Results and documents

Annex IV summary of results, Annex V layperson summary, and all documents registered in CTIS for this trial

Documents 5 files

Public protocol annexes, IB summaries, regulatory submissions and post-authorisation documents registered in CTIS.

TypeTitleVersion
Protocol (for publication) Tutkimussuunnitelma NA
Recruitment arrangements (for publication) Recruitment arrangements 1
Subject information and informed consent form (for publication) Tiedote ja suostumus_clean 4
Summary of Product Characteristics (SmPC) (for publication) Dexametason_valmisteyhteenveto 1
Summary of Product Characteristics (SmPC) (for publication) SmPC_Ropivacain 1

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-12-11 Finland Acceptable
2025-01-21
2025-01-21