A phase 1, controlled, open-label, single dose, dose-escalation, clinical proof-of-concept study of MRI enhanced with ADx-001 (DSPE-DOTA-Gd Liposomal Injection) in patients with brain amyloid deposits as demonstrated by amyloid PET

2024-520078-36-00 Protocol ADx-001-101-POC Human pharmacology (Phase I) - First administration to humans Ended

End 9 Aug 2025 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol ADx-001-101-POC

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ended
Participants planned 18
Countries 1
Sites 1

Alzheimer's disease

Key facts

Sponsor
Alzeca Biosciences Inc.
Participant type
Patients, Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Nervous System Diseases [C10]
Trial duration
completed 9 Aug 2025
Decision date (initial)
2025-01-17
Transition trial
Yes
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2024-520078-36-00
EudraCT number
2021-003399-14
ClinicalTrials.gov
NCT05453539

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Alzheimer's disease

VersionLevelCodeTermSystem organ class
20.0 LLT 10001896 Alzheimer's disease 10029205

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Alzeca Biosciences Inc.

Sponsor organisation
Alzeca Biosciences Inc.
Address
1800 Bering Drive Suite 850
City
Houston
Postcode
77057-3172
Country
United States

Scientific contact point

Organisation
Alzeca Biosciences Inc.
Contact name
Clinical trial coordinators

Public contact point

Organisation
Alzeca Biosciences Inc.
Contact name
Clinical trial coordinators

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 18 1
Rest of world 0

Investigational sites

Germany

1 site · Ended
Klinikum der Universitaet Muenchen AöR
Radiology, Marchioninistrasse 15, Hadern, Munich

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-01-13 Germany Acceptable
2025-01-14
2025-01-17