Safety and Preliminary Clinical Efficacy of MT-302 with CapOx based regimens in metastatic esophagogastric cancer (SPaCE-MT)

2024-520213-45-00 Phase I and Phase II (Integrated) - Other Ongoing, recruiting

Start 15 Aug 2025 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - Other
Status Ongoing, recruiting
Participants planned 61
Countries 1
Sites 1

metastatic esophagogastric cancer

Key facts

Sponsor
Amsterdam UMC Stichting
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
15 Aug 2025 → ongoing
Decision date (initial)
2025-07-01
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

metastatic esophagogastric cancer

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Amsterdam UMC Stichting

Sponsor organisation
Amsterdam UMC Stichting
Address
De Boelelaan 1117
City
Amsterdam
Postcode
1081 HV
Country
Netherlands

Scientific contact point

Organisation
Amsterdam UMC Stichting
Contact name
Hanneke van Laarhoven

Public contact point

Organisation
Amsterdam UMC Stichting
Contact name
Hanneke van Laarhoven

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Ongoing, recruiting 61 1
Rest of world 0

Investigational sites

Netherlands

1 site · Ongoing, recruiting
Amsterdam UMC Stichting
Medische Oncologie, De Boelelaan 1117, 1081 HV, Amsterdam

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2025-08-15 2025-08-17

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-03-12 Netherlands Acceptable
2025-06-30
2025-07-01
2 SUBSTANTIAL MODIFICATION SM-1 2025-08-12 Netherlands Acceptable 2025-08-21
3 SUBSTANTIAL MODIFICATION SM-2 2025-12-24 Netherlands Acceptable
2026-04-09
2026-04-09