NON-IV: Neo-adjuvant peritumOral immuNotherapy In Vulvar cancer

2025-520712-34-00 Protocol 31123 Human pharmacology (Phase I) - Other Authorised, recruiting

Start 4 Feb 2026 · Status Authorised, recruiting · 1 EU/EEA countries · 2 sites · Protocol 31123

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Authorised, recruiting
Participants planned 24
Countries 1
Sites 2

Vulvar Cancer

Key facts

Sponsor
Amsterdam UMC Stichting
Participant type
Patients
Age range
18-64 years
Gender
Female
Therapeutic area
Diseases [C] - Neoplasms [C04], Diseases [C] - Female Urogenital Diseases and Pregnancy Complications [C13]
Trial duration
4 Feb 2026 → ongoing
Decision date (initial)
2025-08-14
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Vulvar Cancer

VersionLevelCodeTermSystem organ class
20.0 PT 10047741 Vulval cancer 100000004864
28.0 PT 10047746 Vulval cancer stage I 100000004864
28.0 PT 10047747 Vulval cancer stage II 100000004864

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Amsterdam UMC Stichting

Sponsor organisation
Amsterdam UMC Stichting
Address
De Boelelaan 1117
City
Amsterdam
Postcode
1081 HV
Country
Netherlands

Scientific contact point

Organisation
Amsterdam UMC Stichting
Contact name
Stijn Mom

Public contact point

Organisation
Amsterdam UMC Stichting
Contact name
Stijn Mom

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Authorised, recruiting 24 2
Rest of world 0

Investigational sites

Netherlands

2 sites · Authorised, recruiting
Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting
Gynaecologie, Plesmanlaan 121, 1066 CX, Amsterdam
Amsterdam UMC Stichting
Verloskunde & Gynaecologie, Meibergdreef 9, 1105 AZ, Amsterdam

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2026-02-04

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-05-16 Netherlands Acceptable
2025-08-13
2025-08-14
2 NON SUBSTANTIAL MODIFICATION NSM-1 2025-12-16 Netherlands Acceptable
2025-08-13
2025-12-16