Phase I, Open-Label Study to Evaluate the Pharmacokinetics, Safety and Tolerability of BIA 28-6156 in Participants with Varying Degrees of Renal Impairment

2025-520754-11-00 Protocol BIA-28-6156-111 Human pharmacology (Phase I) - Other Ongoing, recruiting

Start 25 Aug 2025 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol BIA-28-6156-111

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ongoing, recruiting
Participants planned 40
Countries 1
Sites 1

Parkinson's disease

Key facts

Sponsor
Bial R&D Investments S.A.
Participant type
Healthy volunteers, Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Nervous System Diseases [C10]
Trial duration
25 Aug 2025 → ongoing
Decision date (initial)
2025-08-22
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Parkinson's disease

VersionLevelCodeTermSystem organ class
20.0 PT 10061536 Parkinson's disease 100000004852

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Bial R&D Investments S.A.

Sponsor organisation
Bial R&D Investments S.A.
Address
Avenida Da Siderurgia Nacional, Sao Mamede Do Coronado Sao Mamede Do Coronado
City
Trofa
Postcode
4745-457
Country
Portugal

Scientific contact point

Organisation
Bial R&D Investments S.A.
Contact name
-

Public contact point

Organisation
Bial R&D Investments S.A.
Contact name
-

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Hungary Ongoing, recruiting 40 1
Rest of world 0

Investigational sites

Hungary

1 site · Ongoing, recruiting
CRU Hungary Kft.
N/A, Semmelweis Ter 1, 2143, Kistarcsa

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Hungary 2025-08-25 2025-08-29

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-05-22 Hungary Acceptable
2025-08-12
2025-08-22
2 NON SUBSTANTIAL MODIFICATION NSM-1 2025-09-30 Hungary Acceptable
2025-08-12
2025-09-30
3 SUBSTANTIAL MODIFICATION SM-1 2025-11-04 Hungary Acceptable
2025-11-28
2025-12-10