A clinical trial to learn how liver function affects the blood levels of DAK539 in people with advanced cancer

2025-521001-40-00 Protocol CDAK539A12103 Human pharmacology (Phase I) - Other Authorised, recruitment pending

Status Authorised, recruitment pending · 3 EU/EEA countries · 10 sites · Protocol CDAK539A12103

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Authorised, recruitment pending
Participants planned 24
Countries 3
Sites 10

Advanced Malignancies and Hepatic Impairment

Key facts

Sponsor
Novartis Pharma AG
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Decision date (initial)
2026-04-10
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2025-521001-40-00
WHO UTN
U1111-1331-8654

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Advanced Malignancies and Hepatic Impairment

VersionLevelCodeTermSystem organ class
28.0 SOC 10029104 Neoplasms benign malignant and unspecified (incl cysts and polyps) 2

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Novartis Pharma AG

Sponsor organisation
Novartis Pharma AG
Address
Lichtstrasse 35
City
Basel
Postcode
4056
Country
Switzerland

Scientific contact point

Organisation
Novartis Pharma AG
Contact name
Novartis Pharma Arzneimittel GmbH

Public contact point

Organisation
Novartis Pharma AG
Contact name
Novartis Pharma Arzneimittel GmbH

Locations

3 EU/EEA countries · 10 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Authorised, recruitment pending 3 2
Italy Authorised, recruitment pending 6 3
Spain Authorised, recruitment pending 10 5
Rest of world
United Kingdom
5

Investigational sites

France

2 sites · Authorised, recruitment pending
Centre Hospitalier Universitaire De Bordeaux
Oncologie Médicale, 1 Rue Jean Burguet, 33000, Bordeaux
Centre Hospitalier Universitaire De Nantes
Oncologie Médicale, Boulevard Du Professeur Jacques Monod, 44800, Saint Herblain

Italy

3 sites · Authorised, recruitment pending
Istituto Europeo Di Oncologia S.r.l.
Divisione di Sviluppo di Nuovi Farmaci per Terapie Innovative, Via Giuseppe Ripamonti 435, 20141, Milan
Istituto Di Candiolo Fondazione Del Piemonte Per L'Oncologia IRCCS
Medical Oncology, Strada Provinciale 142 Orba Km 3,95, 10060, Candiolo
Ospedale San Raffaele S.r.l.
U.O Oncologia Medica, Via Olgettina 60, 20132, Milan

Spain

5 sites · Authorised, recruitment pending
Hospital Universitario Hm Sanchinarro
Oncology, Calle Ona 10, 28050, Madrid
Hospital Universitario Quironsalud Madrid
Oncology, Calle De Diego De Velazquez 1, 28223, Pozuelo De Alarcon
Hospital Universitario Fundacion Jimenez Diaz
Oncology, Avenida De Los Reyes Catolicos 2, 28040, Madrid
Hospital Hm Nou Delfos
Oncology, Avinguda De Vallcarca 151, 08023, Barcelona
Hospital Quironsalud Barcelona
Oncology, Placa D'alfonso Comin 5-7, 08023, Barcelona

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-11-28 Italy Acceptable
2026-04-07
2026-04-09