First in human pilot study to assess the safety and efficacy of dendritic cells loaded with frameshift derived neopeptides for the prevention of cancer in Lynch Syndrome carriers

2025-521109-42-00 Protocol DELAY Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 1 Aug 2025 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol DELAY

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 20
Countries 1
Sites 1

Lynch Syndrome

Key facts

Sponsor
Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Phenomena and Processes [G] - Genetic Phenomena [G05]
Trial duration
1 Aug 2025 → ongoing
Decision date (initial)
2025-06-13
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Lynch Syndrome

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer

Sponsor organisation
Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer
Address
Calle Rosellon 149-153
City
Barcelona
Postcode
08036
Country
Spain

Scientific contact point

Organisation
Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer
Contact name
Laura Burunat Ruesgas

Public contact point

Organisation
Fundacio De Recerca Clinic Barcelona-Institut D’Investigacions Biomediques August Pi I Sunyer
Contact name
Laura Burunat Ruesgas

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Spain Ongoing, recruiting 20 1
Rest of world 0

Investigational sites

Spain

1 site · Ongoing, recruiting
Hospital Clinic De Barcelona
Gastroenterology, Calle Villarroel 170, 08036, Barcelona

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Spain 2025-08-01 2025-08-07

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-02-28 Spain Acceptable
2025-06-13
2025-06-13