Single-centre, randomised, double-blind, split-face comparative design clinical trial to evaluate the efficacy and safety of the topical formulation with 4% hydroquinone and 0,025% tretinoin versus the formulation with 4% hydroquinone in patients with facial melasma

2025-521806-16-00 Protocol MED-004-EC-25 Phase I and Phase II (Integrated) - First administration to humans Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites · Protocol MED-004-EC-25

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - First administration to humans
Status Authorised, recruitment pending
Participants planned 21
Countries 1
Sites 1

facial melasma

Key facts

Sponsor
Mesoestetic Pharma Group S.L.
Participant type
Patients
Age range
18-64 years
Gender
Female
Therapeutic area
Diseases [C] - Skin and Connective Tissue Diseases [C17]
Decision date (initial)
2026-05-05
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

facial melasma

VersionLevelCodeTermSystem organ class
21.1 LLT 10027161 Melasma 10040785

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Mesoestetic Pharma Group S.L.

Sponsor organisation
Mesoestetic Pharma Group S.L.
Address
Calle Tecnologia 25
City
Viladecans
Postcode
08840
Country
Spain

Scientific contact point

Organisation
Mesoestetic Pharma Group S.L.
Contact name
Félix Rovira

Public contact point

Organisation
Mesoestetic Pharma Group S.L.
Contact name
Félix Rovira

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Spain Authorised, recruitment pending 21 1
Rest of world 0

Investigational sites

Spain

1 site · Authorised, recruitment pending
Hospital Universitario Hm Torrelodones
Oftalmologia, Avenida Del Castillo De Olivares S/n, 28250, Torrelodones

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-01-16 Spain Acceptable with conditions
2026-05-04
2026-05-05
2 NON SUBSTANTIAL MODIFICATION NSM-1 2026-05-07 Spain Acceptable with conditions
2026-05-04
2026-05-07