First-in-Human trial of DS9051b in participants with advanced solid tumors

2025-521886-28-00 Protocol DS9051-079 Human pharmacology (Phase I) - First administration to humans Authorised, recruiting

Start 19 Feb 2026 · Status Authorised, recruiting · 1 EU/EEA countries · 2 sites · Protocol DS9051-079

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Authorised, recruiting
Participants planned 40
Countries 1
Sites 2

Advanced or Metastatic Adrenocortical Carcinoma (ACC), Metastatic Castration-resistant Prostate Cancer (CRPC)

Key facts

Sponsor
Daiichi Sankyo Inc.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
19 Feb 2026 → ongoing
Decision date (initial)
2025-12-03
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Advanced or Metastatic Adrenocortical Carcinoma (ACC), Metastatic Castration-resistant Prostate Cancer (CRPC)

VersionLevelCodeTermSystem organ class
26.1 PT 10062904 Hormone-refractory prostate cancer 100000004864
21.0 PT 10036911 Prostate cancer recurrent 100000004864
21.1 LLT 10002223 Anaplastic adrenocortical carcinoma 10029104
24.1 LLT 10085680 Advanced prostate cancer 100000004848
24.1 LLT 10085680 Advanced prostate cancer 100000004848
20.0 PT 10001388 Adrenocortical carcinoma 100000004864
20.0 PT 10060862 Prostate cancer 100000004864
21.1 LLT 10012788 Differentiated adrenocortical carcinoma 10029104
27.0 LLT 10086830 Hormone-refractory prostate cancer metastatic 100000004848
27.0 LLT 10086830 Hormone-refractory prostate cancer metastatic 100000004848
20.0 LLT 10007113 Cancer of prostate 10029104
21.1 LLT 10076506 Castration-resistant prostate cancer 10029104
21.1 LLT 10076506 Castration-resistant prostate cancer 10029104
24.1 LLT 10085679 Locally advanced prostate cancer 100000004848
26.1 PT 10062904 Hormone-refractory prostate cancer 100000004864
27.0 PT 10036909 Prostate cancer metastatic 100000004864
24.1 LLT 10085679 Locally advanced prostate cancer 100000004848
20.0 PT 10060862 Prostate cancer 100000004864
20.0 LLT 10007113 Cancer of prostate 10029104
21.0 PT 10036911 Prostate cancer recurrent 100000004864
27.0 PT 10036909 Prostate cancer metastatic 100000004864

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Daiichi Sankyo Inc.

Sponsor organisation
Daiichi Sankyo Inc.
Address
211 Mount Airy Road
City
Basking Ridge
Postcode
07920-2311
Country
United States

Scientific contact point

Organisation
Daiichi Sankyo Inc.
Contact name
Clinical Trial Office

Public contact point

Organisation
Daiichi Sankyo Inc.
Contact name
Clinical Trial Office

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Authorised, recruiting 15 2
Rest of world
United States, United Kingdom
25

Investigational sites

France

2 sites · Authorised, recruiting
Oncopole Claudius Regaud
Oncologie Médical, 1 Avenue Irene Joliot Curie, 31059, Toulouse Cedex 9
Centre Oscar Lambret
Oncologie Médical, 3 Rue Frederic Combemale, 59000, Lille

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2026-02-19

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-09-17 France Acceptable
2025-12-03
2025-12-03
2 SUBSTANTIAL MODIFICATION SM-1 2025-12-10 France Acceptable 2026-01-07
3 NON SUBSTANTIAL MODIFICATION NSM-1 2026-01-23 France Acceptable 2026-01-23