Study Investigating Tucatinib and Osimertinib Pharmacokinetics in Primary and Metastatic Brain Tumors: the STICK trial

2025-522128-28-00 Human pharmacology (Phase I) - Other Authorised, recruiting

Start 26 May 2026 · Status Authorised, recruiting · 1 EU/EEA countries · 1 sites

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Authorised, recruiting
Participants planned 20
Countries 1
Sites 1

Breast cancer

Key facts

Sponsor
Amsterdam UMC Stichting
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
26 May 2026 → ongoing
Decision date (initial)
2025-10-15
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Breast cancer

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Amsterdam UMC Stichting

Sponsor organisation
Amsterdam UMC Stichting
Address
De Boelelaan 1117
City
Amsterdam
Postcode
1081 HV
Country
Netherlands

Scientific contact point

Organisation
Amsterdam UMC Stichting
Contact name
Anne-Jaël Elskamp

Public contact point

Organisation
Amsterdam UMC Stichting
Contact name
Anne-Jaël Elskamp

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Authorised, recruiting 20 1
Rest of world 0

Investigational sites

Netherlands

1 site · Authorised, recruiting
Amsterdam UMC Stichting
Clinical Pharmacology and Pharmacy, De Boelelaan 1117, 1081 HV, Amsterdam

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2026-05-26

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-07-10 Netherlands Acceptable
2025-10-10
2025-10-15
2 NON SUBSTANTIAL MODIFICATION NSM-1 2026-02-25 Netherlands Acceptable
2025-10-10
2026-02-25