A study to learn how safe nurandociguat is when taken with sildenafil in men with arterial hypertension.

2025-522336-14-00 Protocol 22598 Human pharmacology (Phase I) - Other Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 2 sites · Protocol 22598

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Authorised, recruitment pending
Participants planned 36
Countries 1
Sites 2

Chronic Kidney Disease

Key facts

Sponsor
Bayer AG
Participant type
Patients
Age range
18-64 years
Gender
Male
Therapeutic area
Diseases [C] - Cardiovascular Diseases [C14]
Decision date (initial)
2025-11-12
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Chronic Kidney Disease

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Bayer AG

Sponsor organisation
Bayer AG
Address
-
City
Leverkusen
Postcode
51368
Country
Germany

Scientific contact point

Organisation
Bayer AG
Contact name
Therapeutic Area Head

Public contact point

Organisation
Bayer AG
Contact name
Therapeutic Area Head

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Authorised, recruitment pending 36 2
Rest of world 0

Investigational sites

Germany

2 sites · Authorised, recruitment pending
CRS Clinical Research Services Mannheim GmbH
NA, Grenadierstrasse 1, Neckarstadt, Mannheim
CRS Clinical Research Services Berlin GmbH
NA, Siemensdamm 65, Siemensstadt, Berlin

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-09-26 Germany Acceptable
2025-11-12
2025-11-12
2 NON SUBSTANTIAL MODIFICATION NSM-1 2025-12-02 Germany Acceptable
2025-11-12
2025-12-02
3 NON SUBSTANTIAL MODIFICATION NSM-2 2026-02-04 Germany Acceptable
2025-11-12
2026-02-04
4 SUBSTANTIAL MODIFICATION SM-1 2026-02-27 Germany Acceptable
2026-03-05
2026-03-11
5 NON SUBSTANTIAL MODIFICATION NSM-3 2026-03-12 Germany Acceptable
2026-03-05
2026-03-12