A Phase 1 Study of NDI-219216 in Patients with Advanced Solid Tumors with and without Microsatellite Instability and/or Deficient Mismatch Repair

2025-522774-36-00 Protocol 9216-101 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 24 Oct 2025 · Status Ongoing, recruiting · 4 EU/EEA countries · 7 sites · Protocol 9216-101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 134
Countries 4
Sites 7

Advanced solid tumors

Key facts

Sponsor
Nimbus Wadjet Inc.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
24 Oct 2025 → ongoing
Decision date (initial)
2025-09-15
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2025-522774-36-00
ClinicalTrials.gov
NCT06898450

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Advanced solid tumors

VersionLevelCodeTermSystem organ class
28.0 SOC 10029104 Neoplasms benign malignant and unspecified (incl cysts and polyps) 2

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Nimbus Wadjet Inc.

Sponsor organisation
Nimbus Wadjet Inc.
Address
22 Boston Wharf Road Floor 9
City
Boston
Postcode
02210-3032
Country
United States

Scientific contact point

Organisation
Nimbus Wadjet Inc.
Contact name
Claudia Fehling, Regulatory Lead

Public contact point

Organisation
Nimbus Wadjet Inc.
Contact name
Sean Rossi, Executive Director, Clinical Operations

Locations

4 EU/EEA countries · 7 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ongoing, recruiting 26 3
Ireland Ongoing, recruiting 8 1
Portugal Ongoing, recruiting 10 1
Spain Ongoing, recruiting 10 2
Rest of world
United Kingdom, Australia, United States
80

Investigational sites

France

3 sites · Ongoing, recruiting
Institut Paoli Calmettes
-, 232 Boulevard De Sainte Marguerite, Bp 156, Marseille
Assistance Publique Hopitaux De Paris
Service d’oncologie médicale, 184 Rue Du Faubourg Saint Antoine, 75012, Paris
Centre Hospitalier Universitaire De Poitiers
Pole régionale de cancérologie Service d'Oncologie Médicale, 2 Rue De La Miletrie, 86000, Poitiers

Ireland

1 site · Ongoing, recruiting
Mater Misericordiae University Hospital
Oncology, Eccles Street, D07 R2WY, Dublin 7

Portugal

1 site · Ongoing, recruiting
Start Research Portugal Unipessoal Lda.
Medical Oncology, Rua Castilho 39 8º E, 1250-068, Lisbon

Spain

2 sites · Ongoing, recruiting
Hospital Clinico San Carlos
Medical Oncology, Calle Del Profesor Martin Lagos Sn, 28040, Madrid
Hospital Hm Nou Delfos
Medical Oncology, Avinguda De Vallcarca 151, 08023, Barcelona

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2025-10-29 2025-11-12
Ireland 2025-12-22 2026-01-20
Portugal 2025-10-24 2025-11-06
Spain 2025-10-29 2025-11-07

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-06-20 France Acceptable
2025-09-15
2025-09-15
2 NON SUBSTANTIAL MODIFICATION NSM-1 2025-10-17 France Acceptable
2025-09-15
2025-10-17
3 SUBSTANTIAL MODIFICATION SM-1 2025-12-15 France Acceptable
2026-02-27
2026-02-27