Open label study to investigate patch adhesion of an Esflurbiprofen-containing patch in healthy volunteers

2025-523577-42-00 Protocol TK-254RX-0107 Human pharmacology (Phase I) - Other Ended

Start 6 Jan 2026 · End 12 Mar 2026 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol TK-254RX-0107

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 90
Countries 1
Sites 1

Patch adhesion trial with healthy subjects, therapeutical indication not studied

Key facts

Sponsor
Teikoku Seiyaku Co. Ltd.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Musculoskeletal Diseases [C05]
Trial duration
6 Jan 2026 → 12 Mar 2026
Decision date (initial)
2025-11-13
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Patch adhesion trial with healthy subjects, therapeutical indication not studied

VersionLevelCodeTermSystem organ class
28.0 LLT 10006502 Bruise 10022117
20.0 LLT 10028361 Muscular pain 10028395
20.0 LLT 10028338 Muscle sprains 10022117
21.1 LLT 10028362 Muscular pains 10028395
20.0 LLT 10002549 Ankle sprain 10022117
20.0 LLT 10002550 Ankle sprains and strains 10022117
20.0 LLT 10028337 Muscle sprain 10022117

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Teikoku Seiyaku Co. Ltd.

Sponsor organisation
Teikoku Seiyaku Co. Ltd.
Address
567 Sanbonmatsu
City
Higashikagawa
Postcode
769-2695
Country
Japan

Scientific contact point

Organisation
Teikoku Seiyaku Co. Ltd.
Contact name
Director, Regulatory Strategy & Intelligence

Public contact point

Organisation
Teikoku Seiyaku Co. Ltd.
Contact name
Director, Regulatory Strategy & Intelligence

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 90 1
Rest of world 0

Investigational sites

Germany

1 site · Ended
Prof. Dr. med. Hans-Georg Predel, Deutsche Sporthochschule Köln
Deutsche Sporthochschule Köln, Institut für Kreislaufforschung und Sportmedizin, Am Sportpark Müngersdorf 6, 50933, Köln

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2026-01-06 2026-03-12 2026-01-08 2026-02-28

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-09-12 Germany Acceptable
2025-11-12
2025-11-13
2 NON SUBSTANTIAL MODIFICATION NSM-1 2025-12-15 Germany Acceptable
2025-11-12
2025-12-15