Comparative Bioavailability of Levonorgestrel 52 mg Intrauterine System versus Mirena® in Healthy Pre-Menopausal, Non-Pregnant Female Participants.

2025-523736-39-00 Protocol 2025-LIUD06004-PL-01 Human pharmacology (Phase I) - Bioequivalence study Ongoing, recruiting

Start 29 Dec 2025 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol 2025-LIUD06004-PL-01

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ongoing, recruiting
Participants planned 64
Countries 1
Sites 1

No medical condition.

Key facts

Sponsor
Laboratorios Leon Farma S.A.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Female
Therapeutic area
Not possible to specify
Trial duration
29 Dec 2025 → ongoing
Decision date (initial)
2025-11-10
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

No medical condition.

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Laboratorios Leon Farma S.A.

Sponsor organisation
Laboratorios Leon Farma S.A.
Address
Calle La Vallina S/N, Poligono Industrial Navatejera Poligono Industrial Navatejera
City
Villaquilambre
Postcode
24193
Country
Spain

Scientific contact point

Organisation
Laboratorios Leon Farma S.A.
Contact name
Amparo Amilburu

Public contact point

Organisation
Laboratorios Leon Farma S.A.
Contact name
Amparo Amilburu

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Portugal Ongoing, recruiting 64 1
Rest of world 0

Investigational sites

Portugal

1 site · Ongoing, recruiting
Blueclinical Investigacao E Desenvolvimento Em Saude Lda.
Medical Management, Rua De Sarmento De Beires 153 0 Floor 3rd Floor, 4250-449, Porto

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Portugal 2025-12-29 2025-12-29

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-09-26 Portugal Acceptable with conditions
2025-11-07
2025-11-10
2 NON SUBSTANTIAL MODIFICATION NSM-1 2026-01-02 Portugal Acceptable with conditions
2025-11-07
2026-01-02
3 NON SUBSTANTIAL MODIFICATION NSM-2 2026-01-21 Portugal Acceptable with conditions
2025-11-07
2026-01-21