A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BGB-B2033, Alone or in Combination With Tislelizumab With or Without Bevacizumab, in Participants With Selected Advanced or Metastatic Solid Tumors

2025-524136-19-00 Protocol BGB-B2033-101 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 28 Apr 2026 · Status Ongoing, recruiting · 2 EU/EEA countries · 9 sites · Protocol BGB-B2033-101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 285
Countries 2
Sites 9

Selected Advanced or Metastatic Solid Tumors

Key facts

Sponsor
BeOne Medicines AG
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
28 Apr 2026 → ongoing
Decision date (initial)
2026-04-15
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Selected Advanced or Metastatic Solid Tumors

VersionLevelCodeTermSystem organ class
20.0 PT 10073071 Hepatocellular carcinoma 100000004864
27.0 LLT 10077738 Hepatocellular carcinoma metastatic 10029104
21.0 LLT 10019829 Hepatocellular carcinoma recurrent 10029104
24.0 LLT 10085300 Squamous non-small cell lung cancer 100000004848
21.1 PT 10017758 Gastric cancer 100000004864

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

BeOne Medicines AG

Sponsor organisation
BeOne Medicines AG
Address
Aeschengraben 27
City
Basel
Postcode
4051
Country
Switzerland

Scientific contact point

Organisation
BeOne Medicines AG
Contact name
BeOne Medical Officer

Public contact point

Organisation
BeOne Medicines AG
Contact name
BeOne Medical Officer

Locations

2 EU/EEA countries · 9 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ongoing, recruiting 39 5
Italy Authorised, recruiting 17 4
Rest of world
United States, Korea, Republic of, New Zealand, China, Japan
229

Investigational sites

France

5 sites · Ongoing, recruiting
Hopital Beaujon
Unité Cancer du foie et innovation thérapeutique, 100 Boulevard Du General Leclerc, 92110, Clichy
Centre Hospitalier Universitaire De Nantes
Oncologie Medicale, 1 Place Alexis Ricordeau, 44000, Nantes
Institut Gustave Roussy
Département d'innovation Thérapeutique et des Essais Précoces (DITEP), 39 Rue Camille Desmoulins, 94805, Villejuif Cedex
Institut Regional Du Cancer De Montpellier
Oncologie Medicale, 208 Avenue Des Apothicaires, 34298, Montpellier Cedex 5
Centr Georges Francois Leclerc
Oncologie Medicale, 1 Rue Professeur Marion, 21000, Dijon

Italy

4 sites · Authorised, recruiting
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Medical Oncology, Largo Francesco Vito 1, 00168, Rome
IRCCS Istituto Nazionale Tumori Fondazione Pascale
S.C. Sperimentazioni cliniche, Via Mariano Semmola 52, 80131, Naples
Istituto Oncologico Veneto
Medical Oncology 1 Unit, Via Gattamelata 64, 35128, Padova
Humanitas Mirasole S.p.A.
Operating Unit of Oncology and Hematology, Via Alessandro Manzoni 56, 20089, Rozzano

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2026-04-28 2026-05-07
Italy 2026-04-30

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-12-05 Italy Acceptable
2026-04-14
2026-04-15