A Phase I, Open-label, Multi-center, First-in-human Trial to Investigate E303, in Participants with Advanced Refractory Solid Tumors

2025-524192-24-00 Protocol E303-1001 Human pharmacology (Phase I) - First administration to humans Under evaluation

Status Under evaluation · 1 EU/EEA countries · 3 sites · Protocol E303-1001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Under evaluation
Participants planned 149
Countries 1
Sites 3

advanced refractory solid tumors

Key facts

Sponsor
Samsung Bioepis Co. Ltd.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Decision date (initial)
2026-05-18
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

advanced refractory solid tumors

VersionLevelCodeTermSystem organ class
21.1 LLT 10065147 Malignant solid tumor 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Samsung Bioepis Co. Ltd.

Sponsor organisation
Samsung Bioepis Co. Ltd.
Address
76 Songdogyoyuk Ro
City
Yeonsu
Postcode
21987
Country
Korea, Republic of

Scientific contact point

Organisation
Samsung Bioepis Co. Ltd.
Contact name
Regulatory affairs

Public contact point

Organisation
Samsung Bioepis Co. Ltd.
Contact name
Regulatory affairs

Locations

1 EU/EEA country · 3 investigational sites

By country

CountryMS statusPlanned subjectsSites
Spain Authorised, recruitment pending 40 3
Rest of world
Korea, Republic of, Australia, United States
109

Investigational sites

Spain

3 sites · Authorised, recruitment pending
Institut Catala D'oncologia
#E3032401: N/A, Carretera Canyet S/n, 08916, Badalona
Hospital Hm Nou Delfos
#E3032402: N/A, Avinguda De Vallcarca 151, 08023, Barcelona
Hospital Universitario Hm Sanchinarro
#3032403: N/A, Calle Ona 10, 28050, Madrid

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-01-19 Spain Acceptable with conditions
2026-05-11
2026-05-18