A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

2025-524334-26-01 Protocol CA243-0001 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 26 Mar 2026 · Status Ongoing, recruiting · 1 EU/EEA countries · 2 sites · Protocol CA243-0001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 81
Countries 1
Sites 2

Advanced or metastatic solid tumors

Key facts

Sponsor
Bristol-Myers Squibb Services Unlimited Company
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
26 Mar 2026 → ongoing
Decision date (initial)
2026-02-26
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2025-524334-26-01
WHO UTN
U1111-1330-3304

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Advanced or metastatic solid tumors

VersionLevelCodeTermSystem organ class
21.0 PT 10014733 Endometrial cancer 100000004864
27.0 PT 10057529 Ovarian cancer metastatic 100000004864
27.0 LLT 10027475 Metastatic breast cancer 10029104
21.1 LLT 10065252 Solid tumor 10029104
21.1 LLT 10072737 Advanced breast cancer 10029104
21.0 LLT 10056267 Gastroesophageal cancer 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Bristol-Myers Squibb Services Unlimited Company

Sponsor organisation
Bristol-Myers Squibb Services Unlimited Company
Address
Plaza 254, Blanchardstown Corporate Park 2 Blanchardstown Corporate Park 2
City
Dublin 15
Postcode
D15 T867
Country
Ireland

Scientific contact point

Organisation
Bristol-Myers Squibb Services Unlimited Company
Contact name
GSM-CT

Public contact point

Organisation
Bristol-Myers Squibb Services Unlimited Company
Contact name
GSM-CT

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Denmark Ongoing, recruiting 15 2
Rest of world
Japan, United States
66

Investigational sites

Denmark

2 sites · Ongoing, recruiting
Rigshospitalet
Department of Oncology, Rigshospitalet, Copenhagen, Blegdamsvej 9, 2100, Copenhagen Oe
Odense University Hospital
Phase 1 Unit, Dept. of Oncology, Odense University Hospital, J. B. Winsloews Vej 4, 5000, Odense C

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Denmark 2026-03-26 2026-03-30

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-02-09 Denmark Acceptable
2026-02-26
2026-02-26