An Open-Label, Single-Arm Phase 1 Trial to Evaluate The Safety, Tolerability and Efficacy of Vididencel in Chronic Phase Chronic Myeloid Leukemia Patients with Measurable Residual Disease Unable to Meet Requirements of Treatment Free Remission under Tyrosine Kinase Inhibitor Treatment

2025-524587-37-00 Protocol VITAL-CML Human pharmacology (Phase I) - Other Ongoing, recruiting

Start 31 Mar 2026 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol VITAL-CML

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ongoing, recruiting
Participants planned 24
Countries 1
Sites 1

Chronic Phase Chronic Myeloid Leukemia

Key facts

Sponsor
Mendus B.V.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
31 Mar 2026 → ongoing
Decision date (initial)
2026-03-31
Transition trial
No
Low-intervention
No
Rare-disease indication
Yes
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Chronic Phase Chronic Myeloid Leukemia

VersionLevelCodeTermSystem organ class
28.1 LLT 10052065 Chronic phase chronic myeloid leukaemia 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Mendus B.V.

Sponsor organisation
Mendus B.V.
Address
Emmy Noetherweg 2 K
City
Leiden
Postcode
2333 BK
Country
Netherlands

Scientific contact point

Organisation
Mendus B.V.
Contact name
Tariq Mughal

Public contact point

Organisation
Mendus B.V.
Contact name
Tariq Mughal

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Norway Ongoing, recruiting 24 1
Rest of world 0

Investigational sites

Norway

1 site · Ongoing, recruiting
Helse Bergen HF
Department of Medicine, Haukelandsveien 22, 5021, Bergen

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Norway 2026-03-31 2026-04-20

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-11-26 Norway Acceptable
2026-03-30
2026-03-31