A First-in-Human Clinical Trial to Assess the Safety, Tolerability and Pharmacokinetics of MR-L45 in Healthy Adults

2025-524899-40-00 Protocol MR-L45-101 Human pharmacology (Phase I) - First administration to humans Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites · Protocol MR-L45-101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Authorised, recruitment pending
Participants planned 72
Countries 1
Sites 1

Autosomal Dominant Polycystic Kidney Disease

Key facts

Sponsor
Mironid Limited
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Decision date (initial)
2026-04-01
Transition trial
No
Low-intervention
No
Rare-disease indication
Yes
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Autosomal Dominant Polycystic Kidney Disease

VersionLevelCodeTermSystem organ class
20.0 LLT 10036046 Polycystic kidney autosomal dominant 10010331

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Mironid Limited

Sponsor organisation
Mironid Limited
Address
John Arbuthnott Building, 161 Cathedral Street 161 Cathedral Street
City
Glasgow
Postcode
G4 0RE
Country
United Kingdom

Scientific contact point

Organisation
Mironid Limited
Contact name
Neil Wilkie

Public contact point

Organisation
Mironid Limited
Contact name
Neil Wilkie

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Authorised, recruitment pending 72 1
Rest of world 0

Investigational sites

Netherlands

1 site · Authorised, recruitment pending
Pharmaceutical Research Associates Group B.V.
Program Management, Van Swietenlaan 6, 9728 NZ, Groningen

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-02-20 Netherlands Acceptable
2026-04-01
2026-04-01
2 SUBSTANTIAL MODIFICATION SM-1 2026-05-18 Netherlands Acceptable 2026-05-21