A first in human study of the safety, pharmacokinetics and pharmacodynamics of KLR-003 in healthy participants and patients with immune mediated diseases.

2026-525575-22-00 Protocol KLR003-Clin-004 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 7 May 2026 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol KLR003-Clin-004

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 182
Countries 1
Sites 1

Psoriasis

Key facts

Sponsor
Klear Bio Inc.
Participant type
Healthy volunteers, Patients
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Immune System Diseases [C20], Diseases [C] - Skin and Connective Tissue Diseases [C17]
Trial duration
7 May 2026 → ongoing
Decision date (initial)
2026-04-30
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Psoriasis

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Klear Bio Inc.

Sponsor organisation
Klear Bio Inc.
Address
300 Technology Square
City
Cambridge
Postcode
02139-3515
Country
United States

Scientific contact point

Organisation
Klear Bio Inc.
Contact name
Klear Bio Clinical Team

Public contact point

Organisation
Klear Bio Inc.
Contact name
Klear Bio Clinical Team

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Ongoing, recruiting 182 1
Rest of world 0

Investigational sites

Netherlands

1 site · Ongoing, recruiting
Centre for Human Drug Research
Dermatology, Zernikedreef 8, 2333 CL, Leiden

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2026-05-07 2026-05-13

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-03-23 Netherlands Acceptable
2026-04-30
2026-04-30