Patients in high risk for infantile spasm syndrome (age under 1 yr old): -tuborous sclerosis (not after 11/2023) -large vascular cortical injury (large infarction/hemorrhage/infection/trauma, HIE II-III including MRI-criteria 2b and 3, with also cortical lesions -grade IV intraventricular hemorrhage (including hemorrhagic infarct in brain parenchyma) -grade III-IV PVL (including porencephalic cyst) in preterms

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