Domvanalimab — Drug Intelligence | 13 EU Trials

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13 Registered trials

2 Recruiting

9 Completed trials

7 Sponsors

15 Countries

Phase III

Phase II

Phase III: 4 Phase II: 9

Oversight events:

4 temporary halts 1 urgent safety measure 4 unexpected events across 4 trials

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Indications tested

Triple negative breast cancer 1 Anaplastic thyroid cancer 1 Neuroendocrine carcinoma metastatic 1 Thymic carcinoma 1 Gestational trophoblastic tumour 1 Gastroenteropancreatic neuroendocrine tumour disease 1 Peritoneal mesothelioma malignant 1 Carcinoid tumour 1 Non-small cell lung cancer 1

Sponsors using this IMP

Gilead Sciences Inc. 4 Arcus Biosciences Inc. 3 Hospices Civils De Lyon 2 AstraZeneca AB 1 Fondation Franc.Cancerologie Digestive 1 Fundacion Para El Progreso De La Oncologia En Cantabria 1 Medica Scientia Innovation Research S.L. 1

All trials

13 total

PRODIGE 113 (FFCD 2314) – REWENEC – 01 STUDY Randomized trial of FOLFIRI + Zimberelimab + Domvanalimab vs FOLFIRI with a hybrid synthetic co… Not authorised

2024-519922-19-00 Phase II 1 country Hospices Civils De Lyon
A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Patients With Stage III Unresectabl… Recruiting

2023-506891-28-00 Phase III 10 countries Astrazeneca AB
A Phase II Open-Label Study of Sacituzumab Govitecan in Unresectable Locally Advanced/Metastatic Urothelial Cancer Recruiting

2023-508302-24-00 Phase II 5 countries Gilead Sciences Inc.
An open label, single-arm, phase 2 study of perioperative sacituzumab govitecan in combination with zimberelimab and domvanalimab for patien… Ended

2023-504420-26-00 Phase II 1 country Fundacion Para El Progreso De La Oncologia En Cantabria
Study with Various Immunotherapy Treatments in Participants With Lung Cancer Ended

2022-502916-35-01 Phase II 4 countries Gilead Sciences Inc.
A phase 3 clinical trial of a new combination treatment, domvanalimab and zimberelimab, plus chemotherapy, for people with an upper gastroin… Ended

2023-507522-16-00 Phase III 9 countries Arcus Biosciences Inc.
Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic … Ended

2023-509825-38-00 Phase III 8 countries Gilead Sciences Inc.
A safety and efficacy study of treatment combinations with and without chemotherapy in adult patients with advanced upper gastrointestinal t… Ended

2024-511917-40-00 Phase II 1 country Arcus Biosciences Inc.
IMMUNORARE5 : A national platform of 5 academic phase II trials coordinated by Lyon university hospital to assess the safety and the efficac… Halted

2024-517254-99-00 Phase II 1 country Hospices Civils De Lyon
N/A Ended

2024-513121-22-00 Phase II 3 countries Gilead Sciences Inc.
Phase 3 Study Comparing Zimberelimab with Domvanalimab to Pembrolizumab in Advanced Non-Small Cell Lung Cancer Ended

2022-503071-28-00 Phase III 4 countries Arcus Biosciences Inc.
PRODIGE 111 – DOMZIGAST A randomized phase II study evaluating FOLFIRI vs FOLFIRI plus Domvanalimab (anti-TIGIT) and Zimberelimab (anti-PD1)… Ended

2024-519258-35-00 Phase II 1 country Fondation Franc.Cancerologie Digestive
A PHASE II TRIAL EVALUATING THE SAFETY AND EFFICACY OF THE COMBINATION OF ZIMBERELIMAB, DOMVANALIMAB, AND SACITUZUMAB GOVITECAN AS FIRST-LIN… Ended

2025-521489-80-00 Phase II 1 country Medica Scientia Innovation Research S.L.

Showing 1–13 of 13 trials

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