Phase I – Other

1,064 trials 249 recruiting

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This study is to evaluate the safety and pharmacokinetics of Epcoritamab in Pediatric Patients with Relapsed/ Refractory Aggressive Mature B… Ended

2023-504795-20-00 Relapsed/Refractory Aggressive Mature B-cell Neoplasms 2022-05-20
DESTINY-Breast08 will investigate the safety, tolerability, PK and preliminary anti-tumour activity of T-DXd in combination with other thera… Ended

2023-505690-33-00 Metastatic Breast Cancer 2022-03-11
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7443904 in Combination with Glofitamab in Participants wit… Ended

2023-506699-29-00 Relapsed/Refractory B-Cell Non-Hodgkin’s Lymphoma (r/r 2022-03-03
Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumours Ended

2024-511071-16-00 Solid Tumours 2022-02-10
Study of safety and preliminary efficacy of VAY736 given alone or in combination with other antineoplastic agents in patients with NHL Ended

2024-511489-35-00 Relapsed/refractory Non Hodgkin Lymphoma 2022-01-24
Sarcomas and DDR-Inhibition; a neoadjuvant phase I combined modality study - SADDRIN-1 Ended

2024-514907-32-00 non-metastatic soft tissue sarcoma 2022-01-21
A Proof of Concept Study Non-Randomized, Single-Center Pilot Trial Assessing The Safety/Efficacy Of Dual Targeting Of Peripheral And Central… Ended

2024-518128-66-00 patients with cPRA or TGI ≥ 95% on the deceased donor k 2022-01-11
A study to assess the effect of CC-95251 alone and in combination with anti-cancer drugs in subjects with Acute Myeloid Leukemia and Myelody… Ended

2023-506117-22-00 Acute Myeloid Leukemia and Myelodysplastic Syndromes 2022-01-05
Tolerability of concurrent EBRT + Lu-PSMA for node-positive prostate cancer (PROQURE-1) Ended

2024-514168-15-00 N+M0 prostate cancer 2021-12-17
Phase IB Study to Assess the Safety, Tolerability and Efficacy of PM14 in combination with Atezolizumab in Pretreated Patients with Selected… Ended

2023-509688-25-00 Advanced solid tumors 2021-11-23
A Randomized, Open-Label, Phase 1-2 Study of ASTX727 Low Dose (ASTX727 LD) Extended Schedule in Subjects with Lower Risk (IPSS Low or Interm… Ended

2024-516296-32-00 Myelodysplastic Syndromes (MDS) 2021-11-11
Phase 1b Study of Dato-DXd in Combination with Pembrolizumab with or without Platinum Chemotherapy in Advanced or Metastatic Non-Small Cell … Ended

2023-508003-20-00 Non-small cell lung cancer 2021-09-27
A Drug Absorption Study of MK-3475A in Participants with Solid Tumors Ended

2023-505340-19-00 Advanced or Metastatic Solid Tumors 2021-09-20
Single Dose Pharmacokinetics and Relative Bioavailability of Sayana Press via Upper Arm Injection Relative to Anterior Thigh and Abdomen Ended

2024-513561-39-00 long-term female contraception 2021-09-08
Study to Evaluate the Safety and Efficacy of Treatment with NLM-001 before Standard Chemotherapy plus Zalifrelimab in Patients with Advanced… Ended

2024-518852-22-00 Advanced Pancreatic Cancer 2021-09-03
A study of enfortumab vedotin given in the bladder for treatment of patients with non-muscle invasive bladder cancer (NMIBC). Ended

2023-503388-40-00 Non-muscle invasive bladder cancer 2021-08-24
This study aims to find the best dose of BI 907828 (brigimadlin) in patients with different types of advanced cancer (solid tumors) Ended

2024-511503-41-00 Advanced or metastatic solid tumors 2021-08-13
A study to test different doses of BI 1823911 alone and combined with other medicines in people with different types of advanced cancer with… Ended

2024-512805-18-00 solid tumour harbouring G12C mutation 2021-08-03
A Phase I Study of Belantamab Mafodotin in Multiple Myeloma Participants with Normal and Impaired Hepatic Function Ended

2023-509915-10-00 Relapsed or Refractory Multiple Myeloma 2021-07-27
A Phase 1b Study of the MALT1 Inhibitor JNJ-67856633 and Ibrutinib in Combination in Relapsed or Refractory B cell Non-Hodgkin Lymphoma and … Ended

2024-512689-32-00 Non-Hodgkin lymphoma and chronic lymphocytic leukemia 2021-07-15
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-Tumor Activity of Inavolisib in Combination with Paclit… Ended

2023-506745-33-00 Locally Advanced or Metastatic Solid Tumors 2021-07-12
Clinical trial to assess the safety and efficacy of AloCELYVIR in children, adolescent and young adults with diffuse intrinsic pointine glio… Ended

2022-502516-37-00 Newly diagnosed Diffuse Intrinsic Pointine Glioma (DIPG 2021-07-12
Phase I Clinical Study to Assess Safety and Efficacy of Repotrectinib Combined with Osimertinib in Patients with Advanced, Metastatic EGFR M… Ended

2023-509776-41-00 Non-small cell lung cancer (NSCLC) 2021-06-30
A Phase 1b, Open-Label Study of Eftozanermin Alfa (ABBV-621) in Combination with Bortezomib and Dexamethasone in Subjects with Relapsed or R… Ended

2024-512640-36-00 Multiple Myeloma 2021-05-26