Phase I – Other

1,064 trials 249 recruiting

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An open-label, long-term, safety and tolerability study of SAR445088 in participants with cold agglutinin disease previously treated with SA… Ended

2023-510210-68-00 Autoimmune haemolytic anaemia 2021-05-26
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Belvarafenib as a Single Agent and in Combination with Either Cobimetinib … Ended

2022-503107-21-00 NRAS-mutant advanced cutaneous melanoma 2021-05-14
A Phase 1b Study of AMG 757 in Subjects with Neuroendocrine Prostate Cancer Ended

2024-513316-10-00 Adult subjects with de novo or treatment-emergent neuro 2021-04-20
A Phase 1b, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-64264681 in Combination with JNJ-67856633 in Parti… Ended

2024-512687-66-00 non-Hodgkin lymphoma and chronic lymphocytic leukemia 2021-02-16
A Phase 1 Study of HMPL-306 in Advanced Hematological Malignancies with Isocitrate Dehydrogenase (IDH) Mutations Ended

2024-516369-36-00 - Acute myeloid leukemia - Myelodysplastic syndrome/ My 2021-02-09
A Phase 1 Study of HMPL-306 in Locally Advanced Solid Tumors with IDH mutations Ended

2024-516370-30-00 - Locally advanced or metastatic solid tumors - Cholang 2021-02-09
A Phase 1, Open-Label Study of the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-64264681 in Participants with Non-Hodgkin Lymphoma … Ended

2024-512686-13-00 non-Hodgkin lymphoma and chronic lymphocytic leukemia 2021-01-28
A Study Evaluating the Safety and Pharmacokinetics of Escalating Doses of Forimtamig in Participants With Relapsed or Refractory Multiple My… Ended

2023-504571-25-00 Relapsed or Refractory Multiple Myeloma 2020-10-20
A Study of Oral Tazemetostat in Subjects With Moderate and Severe Liver Impairment With Advanced solid tumors or hematological malignancies Ended

2024-517141-13-00 Advanced solid tumors, or hematological malignancies an 2020-10-07
A study to assess how radium-223 moves through the patients with prostate cancer receiving radium-223 dichloride treatment. Ended

2023-506435-15-00 Prostate cancer 2020-08-25
Investigation the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7248824 in Participants with Angelman Syndrome Ended

2024-514797-45-00 Angelman Syndrome (AS) 2020-08-25
A study of safety and efficacy of novel targeted therapy combinations in adult patients with advanced or metastatic colorectal cancer. Ended

2023-510379-77-00 Advanced or metastatic BRAF V600 colorectal cancer. 2020-08-05
Study to evaluate the addition of an experimental drug, CC-90010, to the usual treatment of brain cancer after surgery Ended

2024-511171-15-00 Subjects with newly diagnosed WHO Grade IV glioblastoma 2020-07-06
Study of MK-4830 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-4830-001) Ended

2023-509542-35-00 Advanced Pancreatic cancer, Unresectable Glioblastoma a 2020-03-02
Safety and pharmacokinetics of ceftolozane/tazobactam in pediatric participants with nosocomial pneumonia Ended

2022-501110-56-00 Nosocomial infection, Pneumonia 2020-02-26
Inhibition of AKT in combination with antibodies targeting the protein HER2 in patients with advanced or metastatic breast cancer and with a… Ended

2023-508826-92-00 Patients with PIK3CA-mutant, HER2-positive locally adva 2020-02-14
A study to find out whether olaparib is safe and well tolerated when administered to children and adolescents Ended

2023-507904-30-00 solid tumors 2020-01-27
Gene Therapy for Pyruvate Kinase Deficiency (PKD): A Phase I Clinical Trial to Evaluate the Safety of the Infusion of Autologous CD34+ Cells… Ended

2024-511520-13-00 Inherited metabolic disorder of the enzyme pyruvate kin 2019-11-04
Pembrolizumab plus autologous dendritic cell vaccine in patients with advanced mesothelioma who have failed prior therapies Ended

2023-508756-19-00 Mesothelioma 2019-10-29
Combining drug-eluting bead chemoembolization and radioembolization for treatment of colorectal liver metastases: DEBIR90Y study Ended

2024-514767-26-00 colorectal liver metastases 2019-10-11
A Phase I, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HMPL-523 in Patients with Re… Ended

2024-515123-11-00 Lymphoma 2019-09-05
A Phase 1b, Multicenter Study to Determine the Dose, Safety, Efficacy and Pharmacokinetics of TRK-950 when Used in Combinations with Selecte… Ended

2024-513915-28-00 Bladder cancer, Cholangiocarcinoma, Colorectal Cancer, 2019-06-14
A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients with Urothelial Carcinoma… Ended

2024-511316-25-00 Urothelial carcinoma (UC) 2019-06-04
A Phase IB Study to determine efficacy and safety of Durvalumab and/or novel anti-cancer agents, with or without chemotherapy, in patients w… Ended

2024-511956-42-00 Metastatic Non-Small Cell Lung Cancer (NSCLC) 2019-05-14