Phase I – First Administration to Humans

783 trials 323 recruiting

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A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors Ended

2024-511286-11-00 Advanced Solid Tumors 2022-06-03
An open-label, phase I multicenter, clinical trial of NECVAX-NEO1 in addition to anti-PD-1 or anti-PD-L1 monoclonal antibody checkpoint inhi… Ended

2024-513716-95-00 Non-Small Cell Lung Cancer, cutaneous melanoma, urothel 2022-05-16
Study of Personalized Neoantigen Specific TCR T cells in the Treatment of Advanced Solid Cancers Ended

2024-518201-18-00 Advanced Solid Cancers 2022-04-28
A Phase 1, Dose Finding Study of CC-92328 in Subjects with Relapsed and/or Refractory Multiple Myeloma. Ended

2023-505079-65-00 Multiple myeloma 2022-04-01
A study testing increasing amounts (doses) of CC-91633 to find out what dose can be tolerated without serious side effects in patients with … Ended

2023-503869-34-00 Acute myeloid leukemia or myelodysplastic syndrome of h 2022-03-15
A Study to Evaluate Safety, Pharmacokinetics, and Preliminary Clinical Activity of RO7276389 Alone and in Combination with Cobimetinib in Pa… Ended

2023-506310-43-00 BRAF-V600 Mutation-Positive Advanced Solid Tumor or BRA 2022-02-15
A First-in-Human Study to Evaluate the Safety and Anti-cancer Activity of the product FS120, which is an Antibody medication, to be administ… Ended

2024-514777-22-00 Advanced Malignancies 2022-02-07
A Study of TAS2940 in Participants With Locally Advanced or Metastatic Solid Tumor Cancer Ended

2023-506922-35-00 Locally Advanced or Metastatic Solid Tumors with EGFR a 2022-01-24
A Phase 1b, Open-Label, Dose-Escalation Trial of the Safety of and Antigen-Specific Immune Responses Elicited by VB.10 NEO in Combination Wi… Ended

2023-509996-18-00 Locally advanced and metastatic solid tumor including n 2022-01-18
NTLA-2001 in Patients with Hereditary Transthyretin Amyloidosis with Polyneuropathy (ATTRv-PN) Ended

2024-511170-69-00 Hereditary Transthyretin Amyloidosis with Polyneuropath 2021-08-17
Study of REGN6569 and Cemiplimab in Adult Patients with Advanced Solid Tumor Malignancies Ended

2022-500868-36-00 Squamous Cell Carcinoma of Head and Neck 2021-08-11
A Phase I Randomised Double-Blind Placebo Controlled Safety Study of Intramyocardial Injection of CLXR-001 in Patients Undergoing Coronary A… Ended

2024-518524-69-00 Ischaemic cardiomyopathy 2021-07-30
A Dose Finding Phase 1 Study of CC-96191 in Subjects with Relapsed or Refractory Acute Myeloid Leukemia Ended

2022-500573-13-00 Relapsed or Refractory Acute Myeloid Leukemia 2021-07-06
A Study of MK-0482 as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-0482-001) Ended

2022-500821-34-00 Advanced Solid Tumors 2021-06-15
A Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax in Combination With Polatuzumab Vedotin Plus Rituximab (R) and Cy… Ended

2023-507497-40-00 Diffuse large B-cell lymphoma (DLBCL), Grade 3B follicu 2021-05-31
An Open-label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination with Atezolizumab in Patients with Locally Ad… Ended

2023-506285-31-00 Locally Advanced or Metastatic Solid Tumors 2021-04-21
A Study with ABBV-155 Alone and in Combination with Taxane Therapy in Adults with Relapsed and/or Refractory Solid Tumors Ended

2024-513625-23-00 Patients with relapsed or refractory solid tumors, incl 2021-03-15
First time in human clinical test using a personalized tissue-engineered blood vessel to treat chronical illness in a vein. Ended

2024-520148-40-00 Chronic venous insufficiency 2021-02-25
A Phase 1, First-in-Human, Dose Escalation Study of the JNJ-75348780 Bispecific Antibody Targeting CD3 and CD22 in Participants with NHL and… Ended

2023-504403-92-00 Relapsed/refractory B-cell Non-Hodgkin Lymphoma (NHL) a 2021-02-15
A Phase 1 Study of TAS0612 in Patients with Locally Advanced or Metastatic Solid Tumors Ended

2024-515175-35-00 Locally Advanced or Metastatic Solid Tumors 2021-02-10
Study of DFF332 alone and in combination with Everolimus or Immuno-oncology therapies in patients with renal cell carcinoma and other select… Ended

2024-513379-41-00 Advanced, relapsed Clear Cell Renal Cell Carcinoma 2021-01-26
Study of JNJ-74856665 in patients with Acute Myeloid Leukemia or Myelodysplastic Syndrome Ended

2024-513918-35-00 Acute myeloid leukemia or Myelodysplastic syndrome 2020-12-22
An open-label Phase 1 study of NEO-PTC-01 in patients with advanced or metastatic melanoma Ended

2023-508524-35-00 Metastatic melanoma 2020-12-01
To Study the Safety and Pharmacokinetics of BLYG8824A in Patients with Locally Advanced or Metastatic Colorectal Cancers Ended

2023-503409-12-00 Locally Advanced or Metastatic Colorectal Cancers (mCRC 2020-10-26