Phase I – First Administration to Humans

783 trials 323 recruiting

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Safety and Tolerability of a Timolol Releasing Intraocular Implant in Subjects With Primary Open-angle Glaucoma Ended

2024-511254-51-00 Glaucoma 2023-02-09
SAD/MAD study with PTC844 Ended

2022-501986-38-00 Auto immune disorders 2022-12-30
A Phase 1, Open-Label, Dose-Escalation and Dose-Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Antitumor Activi… Ended

2022-500115-39-00 Advanced Solid Tumors 2022-12-23
A study to Evaluate AB308 in Combination with AB122 in Participants with Advanced Malignancies (ARC-12) Ended

2024-511116-25-00 Multiple Myeloma 2022-12-13
A First-in-Human Clinical Study with ABBV-CLS-579 alone and in combination in Patients with Advanced Tumor Cancers Ended

2023-507432-20-00 Metastatic or locally advanced tumors 2022-12-10
Phase I study of MGY825 in patients with lung cancer Ended

2023-504350-36-00 Advanced non-small cell lung cancer with or without NFE 2022-11-25
A Phase 1 Open-Label, Safety, Pharmacokinetic and Preliminary Efficacy Study of STRO-002, an Anti-Folate Receptor alpha (FolRα) Antibody Dru… Ended

2024-513708-33-00 Advanced Epithelial Ovarian Cancer (including Fallopian 2022-11-23
Study of RP3 Monotherapy and RP3 in Combination With Nivolumab in Patients With Solid Tumors Ended

2024-512710-17-00 Advanced solid tumors 2022-11-22
DT-9081 trial in participants with advanced solid tumours. Ended

2024-516206-28-00 Participants with advanced ( unresectable, recurrent or 2022-11-17
Investigation of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Subcutaneous Injections of NNC0582-0001 in Healthy Ad… Ended

2023-506928-83-00 Healthy Volunteers 2022-11-12
Study of KITE-222 in Participants With Relapsed/Refractory Acute Myeloid Leukemia Ended

2023-507748-35-00 Acute Myeloid Leukemia 2022-11-08
A Phase 1 Study of SGN-ALPV in Advanced Solid Tumors Ended

2022-500094-14-00 gastroesophageal junction [GEJ] carcinoma 2022-11-08
A first-in-human study to learn how safe the study treatment BAY3018250 is, how it affects the body, how it moves into, through, and out of … Ended

2022-500505-41-00 Acute ischemic stroke 2022-11-08
Study of safety and antitumor activity of GEN1056 in participants with advanced solid tumors Ended

2024-514357-29-00 Advanced solid tumors 2022-11-04
A trial to learn if REGN7999 is safe and well tolerated, and how it works in the body of healthy participants. Ended

2022-500398-15-00 Healthy - R7999 being developed for the treatment of d 2022-10-24
A Phase 1 Study of BMS-986406 as Monotherapy and in Combination in Advanced Tumors Ended

2023-508280-69-00 Advanced Malignant Tumors 2022-10-07
Dose escalation trial of BNT152+153 in patients with cancer Ended

2023-509508-13-00 Various solid tumors that are metastatic or unresectabl 2022-10-04
A study to find out how healthy people tolerate a new drug called S221237. Ended

2024-519381-53-00 Parkinson disease (PD) 2022-10-04
Study of PIT565 in relapsed and/or refractory B-cell malignancies Ended

2023-507430-25-00 Relapsed and/or refractory B-cell Non-Hodgkin lymphoma 2022-10-03
A Phase 1a/1b Study Exploring the Safety and Tolerability of INCB081776 in Participants With Advanced Malignancies Ended

2023-504400-29-00 Advanced malignancies. 2022-09-15
A randomized first-in-human, Phase 1, single-center, observer-blind, active-controlled 3-arm study to evaluate the safety, tolerability, and… Ended

2022-500681-98-00 Influenza 2022-09-14
A Study of SGN-B7H4V in Advanced Solid Tumors Ended

2023-503389-22-00 Fallopian tube cancer 2022-08-31
A Study of HFB301001 in Adult Patients With Advanced Solid Tumors Ended

2023-506402-39-00 Advanced cancer of different organs 2022-07-27
A Phase 1 open-label, first-in-human, multi-center, dose escalation and dose expansion study of CLN-619 administered alone or in combination… Ended

2024-511744-27-00 Solid tumors, Non-Small Cell Lung Cancer, Cervical Canc 2022-06-27