Therapeutic Exploratory (Phase II)

3,454 trials 1,368 recruiting

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Efficacy of psilocybin and trazodone combination in treatment-resistant depression: a randomized controlled proof-of-concept study (PSILOTRA… Pending

2024-512911-34-00 Treatment-resistant depression
Osteoarticular infections on prosthesis: impact of three antibiotic therapies on the digestive microbiota Pending

2024-513298-29-00 Osteoarticular infections on equipment
mFBG PET-CT scan for the imaging of pheochromocytoma Pending

2024-513622-35-00 Pheochromocytoma – endocrine adrenal tumor
OSU6162 as add-on in SSRI/SNRI-resistant depression (ODEN): a double-blind, placebo-controlled evaluation of efficacy and safety Pending

2024-513894-35-00 Depression
Targeted fluorescence endoscopy for detection of the primary cancer lesion in patients with a metastasis of unknown primary tumor in the hea… Pending

2024-513897-23-00 Unknown primary tumour of the head and neck
Efficacy and safety of cannabidiol to patients with advanced prostate cancer Pending

2024-513951-33-00 Prostate cancer
Ketamine infusion for symptomatological improvement of severe borderline personality disorder: a pilot study Pending

2024-514361-19-00 borderline personality disorder
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of PPV-06 Active Immunotherapy… Pending

2024-514388-24-00 Knee osteoarthritis
EVALUATION OF UCPVAX VACCINE +/- PEMBROLIZUMAB COMBINED WITH STANDARD TREATMENT AS ADJUVANT THERAPY IN PATIENTS WITH UNMETHYLATED GLIOBLASTO… Pending

2024-514399-42-00 Glioblastoma
A randomized phase II study of Pembrolizumab (MK-3475) as maintainance therapy in patients with unresectable stage III non-small cell lung … Pending

2024-514701-57-01 non Small Cell Lung Cancer
GeranylGeranylAcetone as prevention for postoperative Atrial Fibrillation (GENIALITY) Pending

2024-514743-28-00 Postoperative Atrial Fibrillation
POSITRON - PsilOcybin with pSychologIcal supporT foR cOcaiNe: a randomised controlled pilot feasibility trial of psilocybin with psychologic… Pending

2024-515147-32-02 Cocaine addiction
The therapeutic potential of psilocybin in anorexia nervosa in young adults Pending

2024-515163-63-00 Anorexia Nervosa
Phase II study of Durvalumab (MEDI4736) plus Total Neoadjuvant Therapy (TNT) in locally advanced rectal cancer (The DUREC trial) Pending

2024-515240-24-00 Locally advanced rectal cancer
Targeting inflammation to reduce 90-day and 1-year postoperative severe morbidity in patients with unfavorable inflammatory profile undergoi… Pending

2024-515333-14-03 Patients scheduled for major surgery for oncologic indi
A Phase 2 Study of NEU-411 in Companion Diagnostic-Positive Participants with Early Parkinson’s Disease Pending

2024-515448-22-00 Parkinson
A Phase II, Open-Label, Single Arm, prospective, multicenter study of niraparib plus dostarlimab in patients with pleural mesothelioma posit… Pending

2024-515555-38-01 NON SMALL CELL LUNG CANCER
Stop Treatment in gout Pending

2024-515714-40-00 Gout adult patients
Study to assess the safety and efficacy of multipotent mesenchymal stem cells administration as a treatment for patients with faecal inconti… Pending

2024-515766-13-00 Fecal incontinence
Neoadjuvant AXITINIB plus AVELUMAB for patients with localized RCC and a moderate to high risk of recurrence Pending

2024-515825-27-00 renal cell carcinoma
VASCULAR AND RENAL IMPACT OF ENDOTHELIN-1 RECEPTOR BLOCKADE IN PATIENTS WITH UNCONTROLLED ARTERIAL HYPERTENSION - ENDOTHELIN-2 Pending

2024-515928-36-00 Uncontrolled arterial hypertension
AUSTRAL trial: An open-label, multicenter, phase II study of radiotherapy followed by durvalumab (MEDI4736) and ceralasertib (AZD6738) in st… Pending

2024-515942-18-01 Stage III NSCLC patients with loco-regional relapse > 1
MAV-RAPA: Prospective evaluation of the efficacy of sirolimus (Rapamune) in the treatment of superficial arteriovenous malformations. Pending

2024-516001-23-00 superficial arteriovenous malformations
Safety and Efficacy of Neoadjuvant immunotherapy with Durvalumab (MEDI 4736) in combination with neoadjuvant chemotherapy (Gemcitabin/Cispla… Pending

2024-516077-72-02 The patient has a histologically-confirmed (ureteroscop