Therapeutic Confirmatory (Phase III)

3,259 trials 1,319 recruiting

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A Double-Masked, Randomized, Placebo-Controlled, Paired Eye Study to Evaluate the Efficacy, Safety and Tolerability of Sepofarsen in Subject… Recruiting

2024-518378-14-00 Leber congenital amaurosis (LCA) 2025-07-11
The additive effect of ketamine in combination with electroconvulsive stimulation (ECS) in major depressive disorder (MDD): a translational … Recruiting

2024-512559-20-01 Major Depressive Disorder (MDD) 2025-07-10
Bevacizumab for the treatment of cerebral RAdiation Induced NecrosiS (BRAINS) study: A multicenter, open-label, randomized clinical trial to… Recruiting

2024-512466-34-00 High grade glioma (HGG) 2025-07-10
A phase 3, open-label, controlled, randomized study of newly diagnosed multiple myeloma treatment, designed to evaluate the efficacy and saf… Recruiting

2024-516418-39-00 Multiple Myeloma 2025-07-09
Prevention of secondary infections by interferon gamma in ICU-acquired sustained immune-suppression: a randomized trial Recruiting

2024-516780-93-00 Sustained immunosuppression 2025-07-09
A Study to Evaluate Tobevibart+Elebsiran in Participants with Chronic HDV Infection Not Virologically Suppressed with Bulevirtide Recruiting

2024-519282-22-00 Chronic Hepatitis D Virus (HDV) Infection 2025-07-09
A study on the immune response and safety of an investigational chickenpox vaccine when given to healthy children 12 to 15 months of age. Recruiting

2024-515869-33-00 Varicella 2025-07-08
A clinical study of sacituzumab tirumotecan with or without pembrolizumab in people with breast cancer (MK-2870-011) Recruiting

2024-516834-36-00 Locally recurrent unresectable or metastatic TNBC with 2025-07-08
A study to evaluate the efficacy of APG-2575 (Lisaftoclax) plus azacitidine (AZA) vs. placebo plus AZA in newly diagnosed adult subjects wit… Recruiting

2024-517247-31-00 Newly Diagnosed Higher Risk Myelodysplastic Syndrome 2025-07-07
Fecal Microbiome Transplantation in Cirrhosis. Randomized, Double-blinded, Placebo-Controlled trial in patients with decompensated cirrhosis… Recruiting

2023-509151-13-00 Decompensated cirrhosis 2025-07-04
A Study of Nivolumab + Relatlimab Fixed-dose Combination with Chemotherapy Versus Pembrolizumab with Chemotherapy in Participants with Non-s… Recruiting

2024-513682-40-01 Non-squamous (NSQ), Stage IV or Recurrent Non-small Cel 2025-07-04
Comprehensive Evaluation of Two Second-Line Therapeutic Approaches for Immune Thrombocytopenia (ITP) – a Pragmatic Randomized Controlled Tri… Recruiting

2023-505573-32-00 Immune Thrombocytopenia (ITP) 2025-07-01
Safety and clinical parameter assessment of self-infusion therapy with Prolastin® in patients with severe AATD Recruiting

2024-515894-80-00 Severe Alpha-1 Antitrypsin Deficiency (AATD) 2025-07-01
A pHase III cluster randomIsed controlled, cross-over, non-inferiority Trial of a short course, High dose AntimicRobials vs conventional dos… Recruiting

2024-514730-21-00 Bacterial infections and mycoses 2025-07-01
A Randomized, Double-blinded, Multicenter, Phase Ⅲ Clinical Study of HLX22 (Recombinant Humanized Anti-HER2 Monoclonal Antibody Injection) i… Recruiting

2024-516633-12-00 Locally advanced/ metastatic gastroesophageal junction 2025-06-30
1. A study to see how well nizubaglustat (AZ-3102) works in participants with GM1 gangliosidosis or GM2 gangliosidosis and how safe it is 2.… Recruiting

2024-515778-28-00 Niemann-Pick type C disease and GM1/GM2 gangliosidoses 2025-06-30
metastatic colorectal cancer Recruiting

2023-504831-42-00 patient with colorectal cancer with hepatic metastasis 2025-06-27
A study to understand if sotagliflozin improves symptoms and is safe in people with hypertrophic cardiomyopathy Recruiting

2024-513869-39-00 Obstructive Cardiomyopathy, Hypertrophic 2025-06-27
The use of sildenafil in patients with univentricular heart after Fontan operation - a pilot SINFON-POL study. Recruiting

2023-503913-31-01 Patients with functionally single ventricle (FSV - func 2025-06-27
A Study of Zasocitinib in Adults with Psoriatic Arthritis Who Have Not Taken Biologic Medicines Recruiting

2024-513111-27-00 Psoriatic Arthritis 2025-06-26
Study to compare the efficacy and safety of a 12-week administration of two fixed-dose combinations (Rosuvastatin 20 mg and Fenofibrate 160 … Recruiting

2024-514289-38-00 Dyslipidaemia 2025-06-26
Therapeutic effect of Hydroxychloroquine on IgA Nephropathy course - QUIgAN Study Recruiting

2024-512653-25-00 IgA nephropathy 2025-06-26
A Long-term Follow-up Study for Subjects Previously Treated with Autologous ex vivo Lentiviral Hematopoietic Stem and Progenitor Cell Gene T… Recruiting

2024-518369-92-00 Wiskott-Aldrich syndrome (WAS) 2025-06-25
TAILORED-PROM: Personalized therapeutic approach for preterm premature rupture of membranes to safely prolong pregnancy, enhance maternal an… Recruiting

2024-520237-77-00 Preterm premature rupture of membrance in pregnancy. 2025-06-24