Alexion Pharmaceuticals Inc.

29 trials 12 recruiting Commercial sponsor

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29 Registered trials

12 Recruiting

15 Completed trials

21 Countries active

30 Unique IMPs

100% Results reported

Phase III

Phase II

Phase III: 19 Phase II/III: 1 Phase II: 7 Phase IV: 1 Phase I (FiH): 1

Oversight events:

1 serious breach 10 temporary halts 3 corrective measures across 5 trials

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100%

15 of 15 completed trials have published summary results (EU CTR Article 37 — 12-month obligation).

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Top indications

Lupus nephritis 2 Cardiac amyloidosis 2 IgA nephropathy 2 Paroxysmal nocturnal haemoglobinuria 1 Acromegaly 1 Hypophosphatasia 1 Neuromyelitis optica spectrum disorder 1 Hypoparathyroidism 1 Familial dilated cardiomyopathy 1 Thrombotic microangiopathy 1

Top IMPs

RAVULIZUMAB 11 ALXN1850 3 DANICOPAN 3 ANSELAMIMAB 2 GEFURULIMAB 2 [ALA1,3,12,GLN10,ARG11,TRP14]PTH(1-14)/[ALA18,22, LYS26]PTHRP(15-36)COOH 1 AAV9-CTNT-COBAG3 1 ALFACALCIDOL 1 ALXN1920 1 ALXN2220 1 ALXN2420 1 ASFOTASE ALFA 1

All trials — page 2

29 total

Study of Ravulizumab in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN) Ended

2023-507977-16-00 Phase II 7 countries RAVULIZUMAB
A Phase 3, Open-label, Single Arm, Multicenter Study of Ravulizumab in Addition to Best Supportive Care in Pediatric Participants (from 1 mo… Ended

2023-507850-33-00 Phase III 4 countries RAVULIZUMAB
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Ravulizumab in Adult and Adolescent Participants who have Thro… Ended

2023-510107-22-00 Phase III 9 countries RAVULIZUMAB
A Phase 3, Open-Label, Single-arm, Multicenter Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Activity, and Safety of Ravulizumab… Ended

2022-502335-19-00 Phase III 2 countries RAVULIZUMAB
STRENSIQ® Immunogenicity Study Ended

2022-502793-17-00 Phase IV 1 country BORTEZOMIB; METHOTREXATE DISODIUM; RITUXIMAB

Showing 25–29 of 29 trials

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