Digestive System Diseases

633 trials 301 recruiting

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Study of GS-5290 in Participants With Moderately to Severely Active Ulcerative Colitis Recruiting

2022-501119-14-01 Ulcerative Colitis 4 2024-04-16
Gut microbiome intervention with EXL01 in combination with nivolumab and FOLFOX as first-line treatment for patients with PD-L1 CPS ≥5 metas… Recruiting

2023-506753-38-00 metastatic gastric adenocarcinoma 4 2024-04-16
Evaluation of EXL01 a new Live Biotherapeutic Product to prevent recurrence of Clostridioides difficile infection in high-risk patients. LIV… Recruiting

2023-506232-32-00 Multiple recurrences of Clostridioides difficile infect 9 2024-04-08
A PHASE I STUDY OF THE CEACAM5 x CD3 ANTIBODY NILK-2301 IN COLORECTAL CANCER Recruiting

2023-508058-24-01 LOCALLY ADVANCED OR METASTATIC LOW TUMOR VOLUME COLOREC 1 2024-04-05
Multicenter randomized Phase III trial evaluating contact X-ray brachytherapy for rectal preservation in intermediate substage rectal adenoc… Recruiting

2023-506885-30-00 Adult patients with intermediate low or mid rectal aden 5 2024-03-26
Safety and feasibility of immuno-OCT Recruiting

2023-506395-27-00 Barrett's esophagus 9 2024-03-15
Efficacy, Safety, and Pharmacokinetics of Guselkumab in Pediatric Participants with Moderately to Severely Active Crohn’s Disease Recruiting

2023-504735-41-00 Moderately to Severely Active Crohn's Disease 5 2024-03-05
A Long-Term Study of Elafibranor in Adult Participants with Primary Biliary Cholangitis (ELFIDENCE) Recruiting

2023-505251-43-00 Primary Biliary Cholangitis 5 2024-02-28
Open label randomized, multicentre, controlled trial of pancreatic enzyme replacement therapy (PERT) for pancreatic exocrine insufficiency (… Recruiting

2023-507367-18-00 Pancreatic exocrine insufficiency 6 2024-02-14
Effect of proton pump inhibitors on the structural integrity of endoscopic sleeve gastroplasty: a single-centre open-label, randomized, cont… Recruiting

2024-517679-18-00 obesity 6 2024-02-09
A randomized, double-blind, placebo-controlled, single and multiple-dose-escalation, phase 1 study in healthy volunteers and patients with u… Recruiting

2023-507547-11-00 Ulcerative colitis 1 2024-02-09
Multicenter Phase 2 study to evaluate the efficacy and safety of Cetuximab in combination with Encorafenib plus Binimetinib as induction tre… Recruiting

2022-502413-29-00 BRAF V600E mutated and microsatellite stable (MSS) adva 4 2024-01-22
Combining anti-PD-L1 immune checkpoint inhibitor durvalumab with TLR-3 agonist rintatolimod in patients with metastatic pancreatic ductal ad… Recruiting

2024-514597-42-00 Metastatic pancreatic cancer 9 2024-01-16
First in human clinical trial to evaluate the safety, tolerability and preliminary efficacy of the bispecific CD276xCD3 antibody CC-3 in pat… Recruiting

2022-503084-15-00 Progressive metastatic solid cancer after failure of es 1 2024-01-12
STEPS-EA trial Recruiting

2023-504905-36-00 Strictures after esophageal atresia repair 11 2024-01-11
Clinical trial of the efficacy and safety of nicotinamide in patients with diabetes mellitus type 2 and liver fibrosis Recruiting

2023-504100-28-00 Hepatic fibrosis 4 2024-01-02
Watch-and-wait strategy to initiate Dostarlimab-based Immunotherapy in localized deficient mismatch repair (dMMR) and/or microsatellite inst… Recruiting

2023-506102-39-00 metastatic gastric cancer 4 2023-12-18
SGM-T1: SGM-101 tumor targeted fluorescence endoscopy in rectal polyps with suspected T1 adenocarcinoma or high grade dysplasia Recruiting

2024-510769-41-00 Early rectal cancer 4 2023-12-07
FAPi-PET imaging of in vivo early fistula healing in perianal Crohn’s disease: PERSIST study Recruiting

2023-505317-25-00 perianal Crohn's fistula 6 2023-11-24
TransNiDeG Recruiting

2023-503349-71-00 Pancreatodudoenectomy 4 2023-10-30
Short or long NAT for BR/LAPC (ADVANTAGE) Recruiting

2022-502117-29-00 Advanced pancreatic cancer 5 2023-10-19
The Pancreatic Enzymes after Gastrectomy Trial Recruiting

2022-501944-14-00 Patients after gastrectomy (total and partial) 5 2023-10-02
FusionVAC22_01: DNAJB1-PRKACA fusion transcript-based peptide vaccine combined with immune checkpoint inhibition for fibrolamellar hepatocel… Recruiting

2022-502869-17-01 tumor entities carrying the oncogenic driver fusion DNA 1 2023-09-26
Infliximab for non-Crohn Anal Fistulas Recruiting

2022-502263-38-00 Anal fistula 4 2023-09-01