Metabolism

53 trials 16 recruiting

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A Phase III Study to assess efficacy, safety, and tolerability of Zibotentan combined with Dapagliflozin, compared to Dapagliflozin, in pati… Ended

2023-504124-26-00 Chronic Kidney Disease and High Proteinuria 5 2024-04-04
A clinical Study to Evaluate Metreleptin Treatment in Subjects with Partial Lipodystrophy over 12-Month Timeframe Ended

2022-501799-24-00 partial lipodystrophy 5 2024-03-07
A study to assess safety and efficacy of Elafibranor in Adult Participants with Primary Sclerosing Cholangitis (PSC) Ended

2024-511370-72-00 Primary Sclerosing Cholangitis 4 2023-03-29
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes (TR… Ended

2023-506082-60-00 Chronic Kidney Disease 4 2023-02-28
A Phase 2, Multicenter, Placebo-Controlled, Randomized, Double-Blind, 48-Week Study to Evaluate the Efficacy and Safety of Combination Thera… Ended

2023-508104-38-00 Noncirrhotic Nonalcoholic Steatohepatitis (NASH) with L 4 2023-02-16
A Phase 3 Open-Label Study of PTC923 (Sepiapterin) in Phenylketonuria Ended

2023-509229-31-00 Metabolic Disorders - Phenylketonuria 5 2022-09-28
Young adults with early-onset obesity treated with semaglutide -The RESETTLE study - a randomized double blind placebo-controlled clinical … Ended

2024-518086-99-00 Obesity 6 2025-10-02
A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients with Overt Hepatic Encep… Ended

2025-521029-34-00 Patients with overt hepatic encephalopathy (OHE) and ac 4 2025-09-18
A Study to Investigate the Response of Participants With Type 2 Diabetes Mellitus on Once-Weekly Retatrutide to Hypoglycemia Ended

2024-518471-63-00 Type 2 Diabetes Mellitus 3 2025-06-03
A randomised, double-blind, placebo controlled, parallel group, multi-centre trial in adult subjects with newly diagnosed type 1 diabetes me… Ended

2023-506545-27-01 Diabetes mellitus, Type 1 4 2025-01-28
Assessment of the exposure-dependent perpetrator characteristics of metamizole on metabolic pathways and the pharmacokinetics of imatinib in… Ended

2024-513463-96-01 Pharmacokinetic trial in healthy volunteers 3 2024-09-11
A trial to learn how well balcinrenone in combination with dapagliflozin works and how safe it is compared to dapagliflozin alone in adults … Ended

2023-509709-63-00 Chronic Kidney Disease and Albuminuria 4 2024-07-30
A Study to evaluate the safety and feasibility of Diamyd® in individuals at risk for Type 1 diabetes Ended

2024-513350-30-00 Type 1 diabetes mellitus 4 2024-07-09
A Phase 1/2, adaptive, open-label, single ascending dose to multiple ascending dose study to evaluate the safety, tolerability, pharmacokine… Ended

2022-502963-39-00 Glycogen storage disease type 1a (GSD1a) 7 2024-06-20
A Phase 3, Randomized, Crossover, Open-Label, Active-Controlled Study of Sepiapterin versus Sapropterin in Participants With Phenylketonuria… Ended

2023-506238-61-00 Phenylketonuria 5 2024-05-10
Open-label study to evaluate metreleptin in children under 6 years of age with generalised lipodystrophy Ended

2022-501781-22-00 Generalised lipodystrophy 5 2024-02-09
CBD, amitriptyline and tramadol drug-drug interaction study Ended

2023-508428-36-00 Neurological assessments 4 2023-12-19
Rivaroxaban sotorasib interaction study Ended

2023-505557-41-00 Healthy subjects 6 2023-11-09
Assessment of the influence of the gut microbiome on tacrolimus pharmacokinetics in healthy volunteers Ended

2023-504405-37-00 Pharmacokinetic trial in healthy volunteers 3 2023-08-02
A phase 2a study of CR9114 in healthy adult participants Ended

2023-505020-57-00 Influenza virus 4 2023-07-10
Tramadol Administered Orally to Healthy Subjects for the Improvement of its Detection in Biological Matrices in the Context of Anti-Doping … Ended

2023-503799-25-00 healthy subjects 3 2023-04-27
A clinical study to evaluate mRNA-3705 in Patients with MMA Ended

2022-502492-32-00 Isolated Methylmalonic Acidemia Due to Methylmalonyl-Co 7 2023-02-03
A Phase IIa Study to assess Safety, Tolerability, and Pharmacodynamics of AZD4831 in Adult Participants with Non-cirrhotic NASH with Fibrosi… Ended

2022-500594-13-00 "Non-Alcoholic Steatohepatatis (NASH) is the progressiv 4 2022-12-14
MORPHINE PHARMACOKINETICS AND –DYNAMICS IN HEALTHY VOLUNTEERS AND PATIENTS WITH OBESITY AND OBSTRUCTIVE SLEEP APNOEA. AN INVESTIGATOR INITI… Ended

2022-500779-29-00 Obesity and Obstructive Sleep apnoea 4 2022-12-01