Metabolism

53 trials 16 recruiting

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Optimizing metformin use in polycystic ovary syndrome - A randomized controlled trial Pending

2023-509259-15-01 Polycystic ovary syndrome 6
An open-label, single-arm extension study to evaluate the long-term safety, tolerability, and efficacy of KL1333 (napazimone) in patients wi… Pending

2025-524367-20-00 Adult patients with primary mitochondrial disease 4
Studies to gain insight how the drugs PCSK9-inhibitors and statins affect cholesterol and bile acid metabolism Pending

2023-505726-34-02 Healthy volunteers 6
Imaging beta cells after gestational diabetes Pending

2024-520392-27-00 Gestational diabetes 4
A study investigating the safety, absorption, and elimination of RO7795068, a new compound that may potentially be used in the treatment of … Pending

2024-519296-25-00 Healthy volunteers 3
Personalized Treatment for Endometriosis: A Study on the Safety and Kinetics of Dienogest in Women with Different Gene Variants Recruiting

2025-521026-15-00 Healthy volunteers 3 2025-12-11
Mass Balance Study of [14C] ABBV-932 in Healthy Male Volunteers Recruiting

2024-514454-75-00 Healthy Volunteers 3 2026-04-16
A study of sepiapterin in participants with phenylketonuria (PKU) (EPIPHENY) Recruiting

2024-514435-20-00 Phenylketonuria 5 2025-12-23
SGLT-2i, Heart, Improvement of Cardiovascular Autonomic Neuropathy Recruiting

2025-521748-39-00 type 2 diabetes 6 2025-11-14
Searching simple biomarkers to phenotype type 2 diabetic patients and personalize their treatment Recruiting

2024-516542-19-00 type 2 diabetes 6 2025-07-08
A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes Mellit… Recruiting

2024-518470-13-00 Diabetes Mellitus 3 2025-05-30
PLUTO - Prevention of CKD progression in type 1 diabetes with Long term Use of SGLTi avoiding kidney hypOxia Recruiting

2023-509450-55-01 Type 1 Diabetes Mellitus with chronic kidney complicati 4 2025-04-01
The OxyTUTION Trial Recruiting

2024-516813-19-00 central diabetes insipidus 4 2025-02-26
A study in people with obesity to test the effects of different doses of BI 456906 compared with semaglutide on glucagon receptor activity i… Recruiting

2024-515417-17-00 No targeted indication. Male and female subjects with o 3 2024-10-01
PRODIG : Prevention of new onset diabetes after transplantation by a short term treatment of Vildagliptin in the early post-transplant perio… Recruiting

2024-516272-14-00 renal transplant 5 2024-08-13
STUDY OF OP-1250 ADMINSTERED AS MONOTHERAPY AND COMPARED TO STANDARD OF CARE FOR THE TREATMENT OF ER+, HER2– ADVANCED OR METASTATIC BREAST C… Recruiting

2023-505871-63-00 ER+, HER2- metastatic breast cancer following endocrine 5 2024-04-08
THE EFFECT OF ABIRATERONE ON THE METABOLISM OF OXYCODONE (ENABLE study) Recruiting

2023-505705-17-00 Males aged  18 years with prostate cancer treated with 6 2024-02-23
A 24-Month, Multi-Centre, Open Label Phase IV Post Authorisation Efficacy Study to Evaluate the Efficacy, Safety and Immunogenicity of Daily… Recruiting

2022-502950-14-00 Partial Lipodystrophy 6 2023-12-08
Phase 1/2 study of mRNA-3705 in participants with Isolated MMA (Extension Study). Recruiting

2022-501997-20-00 participants with isolated methylmalonic acidemia (MMA) 7 2023-12-01
KF2022#1 trial: The effect of fecal microbiota transplantation on CYP enzyme activities Recruiting

2024-518312-40-00 Irritable bowel syndrome 3 2023-01-05
A randomised, controlled, parallel group, open-label trial evaluating the impact of treatment with the GLP-1 analogue semaglutide on weight … Recruiting

2024-513168-24-00 HIV & Obesity 4 2022-06-01
A clinical trial to learn more about the effects of DII235 in people with high levels of lipoprotein(a) Ended

2025-521912-21-00 Cardiovascular risk reduction in participants with elev 4 2026-01-26
An open-label extension multi-centre trial in adult subjects diagnosed with Type 1 diabetes mellitus exploring the effect of long-term Verap… Ended

2024-515234-33-00 Type 1 diabetes mellitus (T1D) 4 2024-11-21
HOPE in Diabetic Kidney Disease (HyperpOlarised PyruvatE in Diabetic Kidney Disease) Ended

2023-508824-36-00 Diabetic Kidney Disease 4 2024-09-24