An open label, randomized, four-period, four-sequence single dose, crossover trial in healthy volunteers to determine the relative bioavailability of Dimenhydrinate 50 mg (Test) administered with and without water vs. Vomex A 50 mg Lösung zum Einnehmen im Beutel (Reference 1) and Biodramina 50 mg Comprimidos (Reference 2)

2022-502420-51-00 Protocol CHE21003 Human pharmacology (Phase I) - Bioequivalence study Ended

Start 23 Oct 2023 · End 13 Dec 2023 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol CHE21003

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ended
Participants planned 14
Countries 1
Sites 1

No therapeutic indication in the current trial with healthy volunteers. The intended indication is for the prophylaxis and symptomatic therapy of nausea and vomiting of various etiologies, especially kinetosis.

Key facts

Sponsor
CCDRD Cooperative Clinical Drug Research and Development AG, Hermes Pharma GmbH
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Nutritional and Metabolic Diseases [C18]
Trial duration
23 Oct 2023 → 13 Dec 2023
Decision date (initial)
2023-10-02
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

No therapeutic indication in the current trial with healthy volunteers. The intended indication is for the prophylaxis and symptomatic therapy of nausea and vomiting of various etiologies, especially kinetosis.

VersionLevelCodeTermSystem organ class
21.1 PT 10054924 Prophylaxis against motion sickness 100000004865
20.0 PT 10027990 Motion sickness 100000004854

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

CCDRD Cooperative Clinical Drug Research and Development AG

Sponsor organisation
CCDRD Cooperative Clinical Drug Research and Development AG
Address
Dahlwitz, Lindenallee 70, Dahlwitz-Hoppegarten Lindenallee 70 Dahlwitz-Hoppegarten
City
Hoppegarten
Postcode
15366
Country
Germany

Scientific contact point

Organisation
CCDRD Cooperative Clinical Drug Research and Development AG
Contact name
Sacha Arsova; MD, PhD

Public contact point

Organisation
CCDRD Cooperative Clinical Drug Research and Development AG
Contact name
Sacha Arsova; MD, PhD

Hermes Pharma GmbH

Sponsor organisation
Hermes Pharma GmbH
Address
Georg-Kalb-Strasse 5, Grosshesselohe Grosshesselohe
City
Pullach I. Isartal
Postcode
82049
Country
Germany

Public contact point

Organisation
Hermes Pharma GmbH
Contact name
Dr. Benjamin Schwenk

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Bulgaria Ended 14 1
Rest of world 0

Investigational sites

Bulgaria

1 site · Ended
Bed space for short term stay at Diagnostic & Consultative Centre 'Ascendent' Ltd.
Bed space for short term stay, 47 'Bacho Kiro' str., 1202, Sofia

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Bulgaria 2023-10-23 2023-12-13 2023-10-23 2023-10-24

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-06-28 Bulgaria Acceptable
2023-08-28
2023-10-02