An Open-label, Single-dose, Parallel-group Study to Evaluate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Aticaprant (JNJ-67953964)

2022-502952-30-00 Protocol 67953964MDD1006 Human pharmacology (Phase I) - Other Ended

Start 4 Aug 2023 · End 22 Jan 2025 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol 67953964MDD1006

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 44
Countries 1
Sites 1

Healthy Adult Participants

Key facts

Sponsor
Janssen - Cilag International
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Psychiatry and Psychology [F] - Mental Disorders [F03]
Trial duration
4 Aug 2023 → 22 Jan 2025
Decision date (initial)
2023-06-30
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy Adult Participants

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Janssen - Cilag International

Sponsor organisation
Janssen - Cilag International
Address
Turnhoutseweg 30
City
Beerse
Postcode
2340
Country
Belgium

Scientific contact point

Organisation
Janssen - Cilag International
Contact name
CTIS Point of Contact

Public contact point

Organisation
Janssen - Cilag International
Contact name
CTIS Point of Contact

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 32 1
Rest of world
United States
12

Investigational sites

Germany

1 site · Ended
APEX Gesellschaft fuer angewandte Pharmakologie und experimentelle Pharmakotherapie mbH
not applicable, Landsberger Strasse 476, Pasing-Obermenzing, Munich

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2023-08-04 2024-08-13 2023-08-23 2024-08-13

Application history

6 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-04-18 Germany Acceptable
2023-06-19
2023-06-30
2 SUBSTANTIAL MODIFICATION SM-1 2023-08-16 Germany Acceptable 2023-08-25
3 SUBSTANTIAL MODIFICATION SM-2 2023-12-01 Germany Acceptable
2023-12-21
2023-12-22
4 SUBSTANTIAL MODIFICATION SM-3 2024-03-04 Germany Acceptable
2024-04-03
2024-04-05
5 SUBSTANTIAL MODIFICATION SM-4 2024-06-12 Germany Acceptable
2024-07-26
2024-07-30
6 NON SUBSTANTIAL MODIFICATION NSM-1 2024-09-11 Germany Acceptable
2024-07-26
2024-09-11