An Open-label, Single-dose Study to Evaluate the Effect of Renal Impairment on the Pharmacokinetics of Aticaprant (JNJ-67953964)

2023-503258-11-00 Human pharmacology (Phase I) - Other Ended

Start 6 Dec 2023 · End 3 Dec 2024 · Status Ended · 1 EU/EEA countries · 2 sites

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 48
Countries 1
Sites 2

Healthy Adult Participants

Key facts

Sponsor
Janssen - Cilag International
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Psychiatry and Psychology [F] - Mental Disorders [F03]
Trial duration
6 Dec 2023 → 3 Dec 2024
Decision date (initial)
2023-11-10
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy Adult Participants

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Janssen - Cilag International

Sponsor organisation
Janssen - Cilag International
Address
Turnhoutseweg 30
City
Beerse
Postcode
2340
Country
Belgium

Scientific contact point

Organisation
Janssen - Cilag International
Contact name
CTIS Point of Contact

Public contact point

Organisation
Janssen - Cilag International
Contact name
CTIS Point of Contact

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 48 2
Rest of world 0

Investigational sites

Germany

2 sites · Ended
APEX Gesellschaft fuer angewandte Pharmakologie und experimentelle Pharmakotherapie mbH
NA, Landsberger Strasse 476, Pasing-Obermenzing, Munich
Charite Research Organisation GmbH
NA, Chariteplatz 1, Mitte, Berlin

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2023-12-06 2024-12-03 2024-01-04 2024-11-26

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-09-04 Germany Acceptable
2023-10-30
2023-11-10
2 SUBSTANTIAL MODIFICATION SM-1 2024-03-04 Germany Acceptable
2024-03-21
2024-04-15
3 SUBSTANTIAL MODIFICATION SM-2 2024-09-18 Germany Acceptable 2024-09-26