A comparative bioavailability of reformulated ibuprofen 2% and 4% oral suspensions (Berlin Chemie AG) and reference ibuprofen (Nurofen®) 200 mg/5 ml oral suspension in healthy male and female adult subjects under fasting conditions: an open-label, randomized, single-dose, three-period, three-treatment, three-sequence crossover study

2023-503703-28-00 Protocol BCLT/22/IBU-BE/001 Human pharmacology (Phase I) - Bioequivalence study Ended

Start 25 Oct 2023 · End 2 Apr 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol BCLT/22/IBU-BE/001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ended
Participants planned 75
Countries 1
Sites 1

In this study will be no subjects involved with any specific medical condition or disease

Key facts

Sponsor
Berlin-Chemie AG
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
25 Oct 2023 → 2 Apr 2024
Decision date (initial)
2023-08-24
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

In this study will be no subjects involved with any specific medical condition or disease

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Berlin-Chemie AG

Sponsor organisation
Berlin-Chemie AG
Address
Glienicker Weg 125, Adlershof Adlershof
City
Berlin
Postcode
12489
Country
Germany

Scientific contact point

Organisation
Berlin-Chemie AG
Contact name
Anja Pagenkopf

Public contact point

Organisation
Berlin-Chemie AG
Contact name
Anja Pagenkopf

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Lithuania Ended 75 1
Rest of world 0

Investigational sites

Lithuania

1 site · Ended
Vilnius University Hospital
Biomedical Research Unit, Santariskiu G. 2, Vilniaus M. Sav., Vilnius

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Lithuania 2023-10-25 2024-04-02 2023-11-06 2024-03-05

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-06-06 Lithuania Acceptable
2023-08-23
2023-08-24
2 SUBSTANTIAL MODIFICATION SM-1 2023-09-06 Lithuania Acceptable
2023-10-11
2023-10-19
3 SUBSTANTIAL MODIFICATION SM-2 2024-01-08 Lithuania Acceptable
2024-01-30
2024-02-23
4 NON SUBSTANTIAL MODIFICATION NSM-1 2024-03-28 Lithuania Acceptable
2024-01-30
2024-03-28
5 NON SUBSTANTIAL MODIFICATION NSM-4 2024-04-16 Lithuania Acceptable
2024-01-30
2024-04-16