A study to investigate the effect of ASTX660 (tolinapant) on the pharmacokinetics of substrates of OCT1, OCT2, and MATE1 in healthy volunteers

2023-503742-31-00 Protocol ASTX660-14 Human pharmacology (Phase I) - Other Ended

Start 23 Oct 2023 · End 23 Dec 2023 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol ASTX660-14

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 40
Countries 1
Sites 1

Not applicable. Healthy Volunteers

Key facts

Sponsor
Taiho Oncology Inc.
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
23 Oct 2023 → 23 Dec 2023
Decision date (initial)
2023-10-23
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Not applicable. Healthy Volunteers

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Taiho Oncology Inc.

Sponsor organisation
Taiho Oncology Inc.
Address
101 Carnegie Center Suite 101
City
Princeton
Postcode
08540-6231
Country
United States

Scientific contact point

Organisation
Taiho Oncology Inc.
Contact name
Taiho Oncology, Inc.

Public contact point

Organisation
Taiho Oncology Inc.
Contact name
Taiho Oncology, Inc.

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Germany Ended 40 1
Rest of world 0

Investigational sites

Germany

1 site · Ended
PAREXEL International GmbH
Early Phase Clinical Unit Berlin, Klinikum Westend Haus 31, Spandauer Damm 130, Berlin

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Germany 2023-10-23 2023-12-22 2023-11-09 2023-12-13

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-07-31 Germany Acceptable
2023-10-17
2023-10-23
2 SUBSTANTIAL MODIFICATION SM-1 2024-09-30 Germany Acceptable
2024-10-10
2024-10-15
3 SUBSTANTIAL MODIFICATION SM-2 2024-10-28 Germany Acceptable
2024-11-21
2024-11-22