Open label, four-period, two-sequence, fully replicated, randomized, single dose pivotal study for the assessment of bioequivalence between Furosemide 500 mg tablets (Test) and Lasix 500 mg tablets (Reference) in healthy male volunteers under fasting conditions

2023-505335-12-00 Protocol FMS-BESD-05-RPM/23 Human pharmacology (Phase I) - Bioequivalence study Not authorised

Status Not authorised · 1 EU/EEA countries · 1 sites · Protocol FMS-BESD-05-RPM/23

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Not authorised
Participants planned 50
Countries 1
Sites 1

Not applicable. The study will be conducted on healthy volunteers.

Key facts

Sponsor
Ratiopharm GmbH
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male
Therapeutic area
Diseases [C] - Female Urogenital Diseases and Pregnancy Complications [C13], Diseases [C] - Male Urogenital Diseases [C12]
Decision date (initial)
2023-10-16
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Not applicable. The study will be conducted on healthy volunteers.

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Ratiopharm GmbH

Sponsor organisation
Ratiopharm GmbH
Address
Graf-Arco-Strasse 3, Donautal Donautal
City
Ulm
Postcode
89079
Country
Germany

Scientific contact point

Organisation
Ratiopharm GmbH
Contact name
Constanze Scheel

Public contact point

Organisation
Ratiopharm GmbH
Contact name
Constanze Scheel

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Romania Not authorised 50 1
Rest of world 0

Investigational sites

Romania

1 site · Not authorised
3s Pharmacological Consultation & Res. S.R.L.
Clinical Research Department, Str Centru Dn2 92 3, 727046, Cumparatura

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-07-03 Romania Not acceptable
2023-10-16
2023-10-16