Randomized, Double Blind, Placebo Controlled "first-in-human" Study to Assess the Safety and Tolerability of Single Ascending Intravenous Doses and Multiple Intravenous Doses of RA0127 in Healthy Young Volunteers

2023-504324-26-00 Protocol RA0127-101 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 20 May 2025 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol RA0127-101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 40
Countries 1
Sites 1

Prevention of infections caused by Gram-negative bacteria

Key facts

Sponsor
Remab Therapeutics S.L.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Bacterial Infections and Mycoses [C01]
Trial duration
20 May 2025 → ongoing
Decision date (initial)
2023-06-12
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Prevention of infections caused by Gram-negative bacteria

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Remab Therapeutics S.L.

Sponsor organisation
Remab Therapeutics S.L.
Address
Calle De Can Domenec S/n
City
Cerdanyola Del Valles
Postcode
08193
Country
Spain

Scientific contact point

Organisation
Remab Therapeutics S.L.
Contact name
Rafael Mañez Mendiluce

Public contact point

Organisation
Remab Therapeutics S.L.
Contact name
Rafael Mañez Mendiluce

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Spain Ongoing, recruiting 40 1
Rest of world 0

Investigational sites

Spain

1 site · Ongoing, recruiting
Hospital Del Mar
IMIM-Hospital del Mar, Passeig Maritim De La Barceloneta 25-29, 08003, Barcelona

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Spain 2025-05-20 2025-05-20

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-03-31 Spain Acceptable
2023-06-12
2023-06-12
2 SUBSTANTIAL MODIFICATION SM-1 2023-11-27 Spain Acceptable
2024-02-26
2024-02-26
3 SUBSTANTIAL MODIFICATION SM-2 2024-07-17 Spain Acceptable
2024-10-03
2024-10-03
4 SUBSTANTIAL MODIFICATION SM-3 2025-01-31 Spain Acceptable
2025-04-24
2025-04-24
5 SUBSTANTIAL MODIFICATION SM-4 2025-06-29 Spain Acceptable
2025-09-01
2025-09-05