Clinical Study of Antibody-Drug Conjugate MYTX-011 in Subjects With Non-Small Cell Lung Cancer

2023-504630-22-00 Protocol MYTX-011-01 Phase I and Phase II (Integrated) - First administration to humans Ended

Start 19 Apr 2024 · End 1 Nov 2025 · Status Ended · 2 EU/EEA countries · 16 sites · Protocol MYTX-011-01

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - First administration to humans
Status Ended
Participants planned 300
Countries 2
Sites 16

Non-Small Cell Lung Cancer

Key facts

Sponsor
Mythic Therapeutics Inc.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
19 Apr 2024 → 1 Nov 2025
Decision date (initial)
2024-02-21
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2023-504630-22-00
ClinicalTrials.gov
NCT05652868

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Non-Small Cell Lung Cancer

VersionLevelCodeTermSystem organ class
21.1 PT 10061873 Non-small cell lung cancer 100000004864

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Mythic Therapeutics Inc.

Sponsor organisation
Mythic Therapeutics Inc.
Address
100 Beaver Street
City
Waltham
Postcode
02453-8400
Country
United States

Scientific contact point

Organisation
Mythic Therapeutics Inc.
Contact name
Helen Chalk

Public contact point

Organisation
Mythic Therapeutics Inc.
Contact name
Helen Chalk

Locations

2 EU/EEA countries · 16 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ended 30 7
Spain Ended 30 9
Rest of world
Taiwan, Korea, Republic of, Australia, United Kingdom, United States
240

Investigational sites

France

7 sites · Ended
Institut Universitaire Du Cancer Toulouse-Oncopole
Medical Oncology, 1 Avenue Irene Joliot Curie, 31059, Toulouse Cedex 9
Institut De Cancerologie De L Ouest
Medical Oncology, Bd Du Professeur Jacques Monod, 44800, St Herblain
Institut Curie
Pneumology, 26 Rue D Ulm, 75005, Paris
Assistance Publique Hopitaux De Marseille
Centre d'essais précoces en Cancérologie de Marseille, 264 Rue Saint Pierre, 13005, Marseille
Institut Gustave Roussy
Medical Oncology, 39 Rue Camille Desmoulins, 94805, Villejuif Cedex
Institut Bergonie
Medical Oncology, 229 Cours De L Argonne, 33000, Bordeaux
Centre Leon Berard
Medical Oncology, 28 Rue Laennec, 69008, Lyon

Spain

9 sites · Ended
Hospital Hm Nou Delfos
Medical Oncology, Avinguda De Vallcarca 151, 08023, Barcelona
Hospital Universitario 12 De Octubre
Medical Oncology, Bloque D, Avenida De Cordoba Sn, Madrid
Hospital Clinico Universitario Lozano Blesa
Medical Oncology, Avenida De San Juan Bosco 15, 50009, Zaragoza
Hospital Universitario Fundacion Jimenez Diaz
Medical Oncology, Avenida De Los Reyes Catolicos 2, 28040, Madrid
Hospital Universitario Ramon Y Cajal
Medical Oncology, Carretera Del Colmenar Viejo Km 9 100, Por El Pardo, Madrid
Instituto Oncologico Dr. Rosell S.L.
Medical Oncology, Calle De Sabino Arana Num. 5, 08028, Barcelona
Instituto De Investigacion Sanitaria Fundacion Para La Investigacion Del Hospital Clinico De Valencia-INCLIVA
Medical Oncology, Avenida Menendez Y Pelayo 4, 46010, Valencia
Hospital Quironsalud Malaga
Medical Oncology, Avenida Imperio Argentina 1, 29004, Malaga
Hospital Universitario Hm Sanchinarro
Medical Oncology, Calle Ona 10, 28050, Madrid

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2024-07-18 2024-08-12 2025-11-01
Spain 2024-04-19 2024-05-20 2025-11-01

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-10-17 Spain Acceptable with conditions
2024-02-19
2024-02-21
2 SUBSTANTIAL MODIFICATION SM-1 2024-05-17 Spain Acceptable
2024-07-22
2024-07-29
3 SUBSTANTIAL MODIFICATION SM-2 2024-09-23 Spain Acceptable
2024-12-02
2024-12-02
4 NON SUBSTANTIAL MODIFICATION NSM-1 2025-01-21 Spain Acceptable
2024-12-02
2025-01-21
5 SUBSTANTIAL MODIFICATION SM-3 2025-02-26 Spain Acceptable
2025-05-14
2025-05-14